Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis

Conclusions
According to Nupr1 status, KIC mice develop tumours that phenocopy human classical or QM-PDAC, respectively, and present differential drug sensitivity, thus becoming attractive models for preclinical drug trials.

Source: Gut - May 5, 2014 Category: Gastroenterology Authors: Cano, C. E., Hamidi, T., Garcia, M. N., Grasso, D., Loncle, C., Garcia, S., Calvo, E., Lomberk, G., Dusetti, N., Bartholin, L., Urrutia, R., Iovanna, J. L. Tags: Pancreas and biliary tract, Pancreatic cancer Source Type: research