SPARC independent drug delivery and antitumour effects of nab-paclitaxel in genetically engineered mice

Conclusions nab-Paclitaxel accumulates and acts in a dose-dependent manner. The interaction of plasma SPARC and albumin-bound drugs is observed at low doses of nab-paclitaxel but is saturated at therapeutic doses in murine tumours. Thus, this study provides important information for future preclinical and clinical trials in PDA using nab-paclitaxel in combination with novel experimental and targeted agents.
Source: Gut - Category: Gastroenterology Authors: Tags: Pancreas and biliary tract, Open access Pancreatic cancer Source Type: research