Mouse Paneth cell antimicrobial function is independent of Nod2

Conclusions
Our data reveal that Nod2 does not directly regulate PC antimicrobial activity in B6 mice. Moreover, we demonstrate that previously reported Nod2-dependent influences on gut microbial composition may be overcome by environmental factors, such as cohousing with WT littermates.

Source: Gut - May 5, 2014 Category: Gastroenterology Authors: Shanahan, M. T., Carroll, I. M., Grossniklaus, E., White, A., von Furstenberg, R. J., Barner, R., Fodor, A. A., Henning, S. J., Sartor, R. B., Gulati, A. S. Tags: Crohn's disease, Open access Inflammatory bowel disease Source Type: research