Temporal detection and analysis of guideline interactions

Conclusion We propose an innovative approach to the detection and analysis of interactions between CPGs considering different sources of temporal information (CPGs, ontological knowledge and execution logs), which is the first one in the literature that takes into account the temporal issues, and accounts for different application scenarios.
Source: Artificial Intelligence in Medicine - Category: Bioinformatics Source Type: research

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Publication date: September 2019Source: Language &Communication, Volume 68Author(s):
Source: Language and Communication - Category: Speech-Language Pathology Source Type: research
Publication date: September 2019Source: Language Sciences, Volume 75Author(s): Piergiorgio Trevisan, Adolfo M. GarcíaAbstractSince their onset more than 50 years ago, both psycholinguistics and neurolinguistics have provided crucial breakthroughs for understanding the cognitive bases of language. Despite their major contributions, however, both fields have been undermined by a tradeoff between ecological validity (i.e., the degree to which tasks reflect the conditions of everyday communication) and experimental control (the manipulation of fine-grained variables, which is typically achieved by matching lists of...
Source: Language Sciences - Category: Speech-Language Pathology Source Type: research
Publication date: Available online 13 September 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Sthanley R. De Lima, Douglas G. Felisbino, Manuela R.S. Lima, Roberto Chang, Mário M. Martins, Luiz Ricardo Goulard Filho, Acácio A. Andrade, Djalmir N. Messias, Roberto R. Dos Santos, Fernando C. Juliatti, Viviane PillaAbstractIn this work, over the course of four seasons (12 months), we have monitored the fluorescence quantum efficiency (η) from two sets (S1 and S2) of fresh natural dye extracts from the leaves of Tradescantia pallida purpurea. The natural dye was extracted in aq...
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
In this study, we provide the first estimates that leverage variation in SNAP purchasing power across markets to examine effects of SNAP on child health. We link panel data on regional food prices to National Health Interview Survey data and use a fixed effects framework to estimate the relationship between local purchasing power of SNAP and children’s health and health care utilization. We find that lower SNAP purchasing power leads to lower utilization of preventive health care and more days of school missed due to illness. We estimate no effect on parent-reported health status.
Source: Journal of Health Economics - Category: Health Management Source Type: research
Conclusions: P. aeruginosa-derived flagellin-induced IL-6 and IL-8 production in bronchial epithelial cells, which partially explains the mechanisms of progression and exacerbation of COPD. Corticosteroids are the most effective treatment for the suppression of flagellin-induced IL-6 and IL-8 production in the bronchial epithelial cells. PMID: 31517562 [PubMed - as supplied by publisher]
Source: Experimental Lung Research - Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research
Authors: Salhi M, Lahmar O, Salah MO, Banić I, Binghao B, Malik W, Hamzaoui K, Turkalj M, Hamzaoui A Abstract OBJECTIVE: Pharmacogenetic studies have recognized specific genes that highly correlate with response to inhaled corticosteroids (ICS) treatment in asthma patients. Among the genes identified, we selected glucocorticoid-induced transcript 1 (GLCCI1) and stress-induced phosphoprotein 1 (STIP1) to evaluate the impact of these gene polymorphisms on ICS treatment response in Tunisian asthmatics. METHODS: We analyzed four single nucleotide polymorphisms (SNPs): two in GLCCI1 (rs37972 and rs37973), and two i...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Kong I, Zhao Y, Wang Y, Chang X, Cui L, Gu G, Ma Z, Lu Q, Zhou L, Ding L, Wang Z, Shao Y, Tang H, Zhang C, Hui F, Mei X, Xin J, Huo J, Sun S, Zhu S, Yao C, Du G, Cheng M, Kang J Abstract Purpose: The aim of this study was to investigate the efficacy and safety of tratinterol hydrochloride in bronchial asthma(BA) treatment. Methods: Patients enrolled in this study were distributed randomly into a treatment group (tratinterol hydrochloride) and an active control group (procaterol hydrochloride) and were treated for 2 weeks after running-in. The end points were changes in pulmonary function and clinical sympt...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Cômes J, Prieur G, Combret Y, Gravier FE, Bonnevie T, Medrinal C PMID: 31514554 [PubMed - as supplied by publisher]
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
This study compared real-world treatment patterns and healthcare costs among biologic-naive patients with PsA initiating apremilast or biologics. Methods: A retrospective cohort study was conducted using the Optum Clinformatics™ claims database. The study included biologic-naive patients with PsA who initiated treatment with apremilast or a biologic between January 1, 2014, and December 31, 2015. Propensity score matching was used to adjust for selection bias. Treatment persistence/adherence and all-cause healthcare costs were evaluated. Cost differences were determined using Wilcoxon rank-sum tests. Results: In all,...
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
Authors: Bragazzi NL, Watad A, Damiani G, Adawi M, Amital H, Shoenfeld Y Abstract Introduction: Due to the polymorphic clinical presentations and manifestations of systemic lupus erythematosus (SLE), biomarkers with enough diagnostic and prognostic value are of paramount importance. Recently, anti-double stranded DNA (anti-dsDNA) auto-antibodies have been proposed to monitor the response to different therapies. It has also been suggested that they should be employed as entry markers in trial studies. However, their clinical use remains still debated and, sometimes, controversial, due to conflicting findings reporte...
Source: Expert Review of Molecular Diagnostics - Category: Laboratory Medicine Tags: Expert Rev Mol Diagn Source Type: research
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