LIM homeobox transcription factor 1B expression affects renal interstitial fibrosis and apoptosis in unilateral ureteral obstructed rats.

In conclusion, reduced LMX1B levels clearly represent a risk factor for renal fibrosis, whereas overexpression affords some level of protection. In general, LMX1B may be considered to be a negative regulator of the fibrosis index, transforming growth factor-βl, collagen-III, fibronectin, cleaved caspase-3, cell apoptosis, reactive oxygen species and malon dialdehyde (r= -0.756, -0.698, -0.921, -0.923, -0.843, -0.794, -0.883, -0.825; each P<0.01).
PMID: 24785190 [PubMed - as supplied by publisher]

Source: Am J Physiol Renal P... - April 30, 2014 Category: Urology & Nephrology Authors: Zhou TB, Ou C, Qin YH, Lei FY, Huang WF, Drummen GP Tags: Am J Physiol Renal Physiol Source Type: research