Research and Reviews in the Fastlane 169

This study confirms this dosage for acute pain in the ED. This was an RCT of ED patients with acute (<30 days) of musculoskeletal, flank, abdominal, or head pain rated at least 5/10. The authors set out to examine mean difference in pain scores between 10mg IV, 15 mg IV, and 30 mg IV and, unsuprisingly, they found no significant difference between mean pain scores. These results are consistent with prior literature and, given side effects of NSAIDs tend to increase in a dose related fashion, it’s a good idea to give the 10mg dose a try. Recommended by: Anand Swaminathan, Jeremy Fried, Lauren Westafer The Best of the Rest Emergency Medicine Freund Y et al. Prognostic Accuracy of Sepsis-3 Criteria for In-Hospital Mortality Among Patients With Suspected Infection Presenting to the Emergency Department. JAMA 2016. doi:10.1001/jama.2016.20328 In 2016, the Sepsis-3 criteria were launched shifting our definition of sepsis to life-threatening organ dysfunction caused by a dysregulated host response to infection. Along with this shift was the change from SIRS to SOFA and qSOFA to predict mortality in septic patients. This article looks to prospectively validate the qSOFA score. Although the study is multinational, it was primarily performed in France (27 out of 30 centers) and found that patients with a qSOFA < 2 had a mortality rate of just 3% versus 24% in the qSOFA >/= 2. The article concludes that this study validates qSOFA and that this tool ...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Administration Clinical Research Education Emergency Medicine Gastroenterology Infectious Disease Pediatrics R&R in the FASTLANE EBM literature recommendations research and reviews Source Type: blogs