Wayne State University research team develops new diagnostic tool to identify tinnitus in animals
(Wayne State University - Office of the Vice President for Research) A team of researchers from Wayne State University has developed a behavioral tool that may significantly aid in understanding the underlying mechanisms of tinnitus, ultimately leading to new drugs and treatment methods.
ConclusionsNone of the four GPMs was sensitive to the improvements in both speech reception and tinnitus that were associated with cochlear implantation. To capture fully the benefits of interventions for auditory disorders, developments of current GPMs would need to be sensitive to both the health-related and non-health-related aspects of auditory dysfunction.
Condition: Tinnitus, Subjective Interventions: Drug: OTO-313; Drug: Placebo Sponsor: Otonomy, Inc. Recruiting
Publication date: Available online 15 April 2019Source: Neuroscience &Biobehavioral ReviewsAuthor(s): Jeffrey Hullfish, William Sedley, Sven VannesteAbstractMore than 150 years have passed since Helmholtz first described perception as a process of unconscious inference about the causes of sensations. His ideas have since inspired a wealth of literature investigating the mechanisms underlying these inferences. In recent years, much of this work has converged on the notion that the brain is a hierarchical generative model of its environment that predicts sensations and updates itself based on prediction errors. Here, we ...
CONCLUSIONS: There was a strong relationship between tinnitus occurrence and TMDs. The findings implied the significance of exploring the signs of TMDs in patients with tinnitus as well as tinnitus in those who complain from temporomandibular disorders. PMID: 30991812 [PubMed - as supplied by publisher]
CONCLUSION: There is low-quality evidence for a positive effect of conservative temporomandibular disorders treatment on tinnitus complaints. The combination of splint therapy and exercise treatment is currently the best investigated treatment approach, showing a decrease in tinnitus severity and intensity. Despite the low level of evidence and the methodologic issues in the included studies, it is noteworthy that all included studies show positive treatment effects. PMID: 30978269 [PubMed - as supplied by publisher]
Conclusion: The presence of stress symptoms, measured by ISSL was observed in most of our patients with chronic subjective tinnitus, specially in the resistance and exhaustion phases and it is directly associated with tinnitus annoyance. PMID: 30972125 [PubMed]
AbstractTinnitus, also known as phantom auditory perception, is an annoying symptom and 13 –17% of population reports bothersome tinnitus. Cochlear synaptic tinnitus is the most common type. Many treatments have been tried but none is yet considered to be well established. To evaluate effect of Inj.Caroverine and Ginkgo Biloba extract in cochlear synaptic tinnitus in terms of improving tinnitus grading, tinnitus matching and quality of life of patient. It is Randomised controlled study, conducted in department of ENT, on 86 patients, who met inclusion criteria, divided into 4 groups. Gr1—Inj Caroverin, Gr2&mdas...
Publication date: Available online 11 April 2019Source: NeurocomputingAuthor(s): Pei-Zhen Li, Ling Huang, Chang-Dong Wang, Chuan Li, Jian-Huang LaiAbstractTinnitus is the phantom perception of sound and can have negative effect on the quality of life. Sudden deafness is generally defined as sensorineural hearing loss of 30 dB or greater over at least three contiguous audiometric frequencies and within a three-day period, which is usually unilateral and can be associated with tinnitus. The exact pathogenesis of such auditory diseases is still unknown, and alterations in the functional connectivity of the brain network are s...
Publication date: Available online 9 April 2019Source: Neuroscience LettersAuthor(s): Leila Faraji, Akram Pourbakht, Hamid HaghaniAbstractIn comodulation masking release (CMR), the auditory signal threshold improves when maskers far from the frequency of the target signal are coherently amplitude-modulated. Studies show that inhibitory function may play a role in CMR. In individuals who have tinnitus, decreasing inhibitory functioning in auditory central nervous system has been documented. Therefore, in this study, the purpose was to evaluate CMR in individuals suffering from tinnitus and compare CMR findings with those wh...
More News: Tinnitus