PLA2G16 represents a switch between entry and clearance of Picornaviridae

This study uncovers two competing processes triggered by virus entry: activation of a pore-activated clearance pathway and recruitment of a phospholipase to enable genome release.

Source: Nature - January 10, 2017 Category: Research Authors: Jacqueline Staring Eleonore von Castelmur Vincent A. Blomen Lisa G. van den Hengel Markus Brockmann Jim Baggen Hendrik Jan Thibaut Joppe Nieuwenhuis Hans Janssen Frank J. M. van Kuppeveld Anastassis Perrakis Jan E. Carette Thijn R. Brummelkamp Tags: Letter Source Type: research