Log in to search using one of your social media accounts:

 

Ludwig study reveals why cancer cells spread within the body

(Ludwig Institute for Cancer Research) Findings uncover an ancient mechanism that makes cancer cells invasive, explains melanoma's resistance to therapy and opens the door to development of novel cancer therapies
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

Related Links:

Publication date: Available online 30 April 2018 Source:Seminars in Cancer Biology Author(s): Tobias Gutting, Elke Burgermeister, Nicolai Härtel, Matthias P. Ebert Immunotherapy is the latest revolution in cancer therapy. It continues to show impressive results in malignancies like melanoma and others. At least so far, effects are modest in colorectal cancer (CRC) and only a subset of patients benefits from already approved checkpoint inhibitors. In this review, we discuss major hurdles of immunotherapy like the immunosuppressive niche and low immunogenicity of CRC next to current achievements of checkpoint inhibitor...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
Abstract In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Tags: Int J Biol Macromol Source Type: research
The majority of cancer deaths are associated with metastasis, the process of cancer cells spreading from primary tumor sites and forming new tumors at distant organs. Circulating tumor cells (CTCs) are the key determinants of metastatic propensity. Detection and characterization of CTCs is critical for understanding tumor metastasis and improving cancer therapy. Here, we applied a linear-array-based photoacoustic tomography (LA-PAT) system for label-free high-throughput melanoma CTC imaging in patients in vivo.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research
Little is known about the impact of melanoma stage and treatment on quality of life (QoL).The Functional Assessment of Cancer Therapy Melanoma (FACT-M) was completed by 87 patients at an academic institution in 2015-2016. Scores were compared between localized and advanced-stage patients. FACT-M scores were converted to European Quality of Life-5 Dimensions (EQ-5D) scores for derivation of health utilities. Melanoma was associated with reduced utility compared to the general population (0.76 vs 0.87, respectively).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research
Conclusion We report the clinical and genomic landscape of a patient with MPTs who had no identifiable unique somatic or germline mutations to explain her predilection to cancer. The treatment course and overall prognosis for this patient is important for understanding future cases with unrelated, metachronous MPTs, the occurrence of which cannot always be explained by underlying genetic mechanisms.
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
The majority of cancer deaths are associated with metastasis, the process of cancer cells spreading from primary tumor sites and forming new tumors at distant organs. Circulating tumor cells (CTCs) are the key determinants of metastatic propensity. Detection and characterization of CTCs is critical for understanding tumor metastasis and improving cancer therapy. Here, we applied a linear-array-based photoacoustic tomography (LA-PAT) system for label-free high-throughput melanoma CTC imaging in patients in vivo.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research
Little is known about the impact of melanoma stage and treatment on quality of life (QoL).The Functional Assessment of Cancer Therapy Melanoma (FACT-M) was completed by 87 patients at an academic institution in 2015-2016. Scores were compared between localized and advanced-stage patients. FACT-M scores were converted to European Quality of Life-5 Dimensions (EQ-5D) scores for derivation of health utilities. Melanoma was associated with reduced utility compared to the general population (0.76 vs 0.87, respectively).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Pigmentation and Melanoma Source Type: research
FINDINGSMelanoma, a relatively rare but deadly skin cancer, has been shown to switch differentiation states — that is, to regress to an earlier stage of development — which can lead it to become resistant to treatment. Now, UCLA researchers have found that melanomas can be divided into four distinct subtypes according to their stages of differentiation. Cell subtypes that de-differentiated — meaning that they reverted back to a less-mature cell — showed sensitivity to a type of self-inflicted cell death called ferroptosis.The research also showed that certain subtypes of melanoma cells could be succ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Melanoma is notoriously resistant to all current modalities of cancer therapies including chemotherapy. In recent years, microRNAs (miRNAs) have emerged as molecular regulators in the development and progressi...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
This study illustrates the importance and potential of utilizes plasmas to manipulate the redox environment for tumor immune control.
Source: Clinical Plasma Medicine - Category: Research Source Type: research
More News: Cancer | Cancer & Oncology | Cancer Therapy | Melanoma | Skin Cancer | Study