Proton Pump Inhibitor Use Is Associated With Extended-Spectrum {beta}-Lactamase-Producing Enterobacteriaceae Rectal Carriage at Hospital Admission: A Cross-Sectional Study

In this cross-sectional study, 8.5% of patients using proton pump inhibitors (PPIs) were rectal carriers of extended-spectrum β-lactamase–producing Enterobacteriaceae (ESBL-E), compared with 2.9% of non-PPI users. In multivariable analysis, PPI use was independently associated with ESBL-E rectal carriage at hospital admission (adjusted odds ratio, 3.89; 95% confidence interval, 1.65 – 9.19).

Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Huizinga, P., van den Bergh, M. K.-, van Rijen, M., Willemsen, I., van 't Veer, N., Kluytmans, J. Tags: Brief Report Source Type: research