Therapeutic Immune Recovery and Reduction of CXCR4-Tropic HIV-1

Conclusion.
Our study demonstrates that X4-tropic HIV sharply declines in most patients during successful therapy, which indicates a preferential tropism-dependent provirus elimination in the immunocompetent host. The recently implemented World Health Organization strategies of immediate therapy initiation are fully in line with this gradual loss of X4 tropism during therapy. Moreover, the early use of coreceptor antagonists against the remaining CCR5-tropic viruses may be indicated.

Source: Clinical Infectious Diseases - January 16, 2017 Category: Infectious Diseases Authors: Bader, J., Däumer, M., Schöni-Affolter, F., Böni, J., Gorgievski-Hrisoho, M., Martinetti, G., Thielen, A., Klimkait, T., for the Swiss HIV Cohort Study Tags: Major Article Source Type: research