Yellow Fever Outbreak In Brazil Could Become An Epidemic, Officials Fear

Public health officials in Brazil suspect that a small yellow fever outbreak in Minas Gerais, a populous landlocked state adjacent to São Paulo state, has infected 110 people and killed 30, according to a Friday report. There is a vaccine for yellow fever, but because the outbreak is taking hold in areas with low vaccination rates, officials are concerned that the disease could continue to spread beyond the state’s borders and cause a larger epidemic, according to the World Health Organization. Yellow fever is spread by the same mosquito that spreads Zika virus, dengue fever and chikungunya.  Brazil’s ministry of health has deployed teams to the state to help investigate the outbreak, kill mosquitos (the virus is mosquito-borne) and immunize residents, all in the hope of containing the outbreak to Minas Gerais. States that border Minas Gerais could experience large outbreaks, WHO notes, because they harbor the Aedes mosquito and the population is not immunized at all against yellow fever, as these areas were previously thought to be low-risk. The country is still recovering from the Zika virus outbreak, another mosquito-borne disease that infected an estimated 214,193 people and resulted in the births of 2,366 infants with congenital Zika syndrome from 2015 to 2017. Minas Gerais has experienced yellow fever epidemics before; the last one was in 2002 to 2003, when 63 people got the fever and 23 people died. Other Brazilian states have exp...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news

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Background: Many of those aging with HIV suffer from distal neuropathic pain (DNP) due to HIV-associated sensory neuropathy (HIV-SN). Prior studies have linked chronic pain conditions to a variant of the catechol-O-methyltransferase (COMT), Val158Met. This variant confers reduced enzymatic activity and results in higher synaptic dopamine levels. Here we examined the role of Val158Met as a predictor of DNP in HIV-SN. Methods: In 1044 HIV-infected individuals enrolled in CNS HIV Antiretroviral Therapy Effects Research, an observational study across six US institutions, we characterized the relationship between Val158Met...
Source: AIDS - Category: Infectious Diseases Tags: CLINICAL SCIENCE Source Type: research
Background: Many individuals failing first-line antiretroviral therapy (ART) in sub-Saharan Africa never initiate second-line ART or do so after significant delay. For people on ART with a viral load more than 1000 copies/ml, the WHO recommends a second viral load measurement 3 months after the first viral load and enhanced adherence support. Switch to a second-line regimen is contingent upon a persistently elevated viral load more than 1000 copies/ml. Delayed second-line switch places patients at increased risk for opportunistic infections and mortality. Methods: To assess the potential benefits of a simplified secon...
Source: AIDS - Category: Infectious Diseases Tags: EPIDEMIOLOGY AND SOCIAL Source Type: research
No abstract available
Source: AIDS - Category: Infectious Diseases Tags: Correspondence Source Type: research
No abstract available
Source: AIDS - Category: Infectious Diseases Tags: Correspondence Source Type: research
[Nation] By the end of Monday, Kenya's birth registry would have recorded about 3,154 newborns.
Source: AllAfrica News: Polio - Category: Infectious Diseases Source Type: news
ConclusionsClinicians providing care for patients receiving moxetumomab pasudotox-tdfk should be aware of the strategies required for safe administration, including the management of serious adverse events.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
AbstractFor many decades, cancer treatment has been strongly directed toward the development of cytotoxic and cytostatic drugs, quite often leading to disappointing results due to the inter- and intra-tumoral heterogeneity. Lately, this intra-cellular look has given way to the understanding of the tumor microenvironment, thus enabling modification of the immunological dynamics between tumor cells and their host. An era of new drugs aiming to unlock the host immune system against tumor cells is steadily increasing. Strategies involving adoptive cell therapy, therapeutic vaccines, immune checkpoint inhibitors and so on have ...
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
ConclusionsThis study indicates that L-OHP treatment specifically upregulated PGE2 secretion by vascular endothelial cells, which may contribute to vascular pain, and that NSAIDs can be used to inhibit PGE2 release and attenuate L-OHP-induced hyperalgesia.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
(Joule Inc.) Strong political support and strong public health systems are necessary to combat measles outbreaks, which are growing in frequency around the world, argue public health experts in a commentary in CMAJ (Canadian Medical Association Journal).
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
Publication date: Available online 13 July 2019Source: Small Ruminant ResearchAuthor(s): C. Jiménez, A. Benito, J.L. Arnal, A. Ortín, M. Gómez, A. López, S. Villanueva-Saz, D. LacastaAbstractOvine anaplasmosis is caused by the obligate intraerythrocytic bacteria Anaplasma ovis and the disease is characterized by anaemia, weight loss and weakness. A severe outbreak of ovine anaplasmosis was diagnosed for the first time in Spain in 2014 and, subsequently, a research was developed in order to increase de knowledge of this not-well-known disease.An experimental infection with Anaplasma ovis was carr...
Source: Small Ruminant Research - Category: Zoology Source Type: research
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