Strong expression of interleukin-17 is associated with higher histologic grades in canine mammary carcinoma

This study investigates interleukin-17 expression in canine mammary tumours by immunohistochemistry and its relationships with histologic grades, tumour recurrence and survival after 2  years. Results showed that 23 samples (63.88%) showed strong immunoreactivity for interleukin-17 and 13 samples (36.11%) showed moderate immunoreactivity. Interleukin-17 expression is significantly increased in canine mammary tumours compared to normal canine mammary tissues (P <  0.05). Furthermore, our results showed that interleukin-17 increased expression is significantly associated with high histologic grade (P <  0.05). Interleukin-17 may be involved in pathogenesis of canine mammary tumours by promoting malignancy grades; however, more investigations are needed to clarify this idea.
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research