Inflammaging and human longevity in the omics era

Publication date: Available online 27 December 2016 Source:Mechanisms of Ageing and Development Author(s): Daniela Monti, Rita Ostan, Vincenzo Borelli, Gastone Castellani, Claudio Franceschi Inflammaging is a recent theory of aging originally proposed in 2000 where data and conceptualizations regarding the aging of the immune system (immunosenescence) and the evolution of immune responses from invertebrates to mammals converged. This theory has received an increasing number of citations and experimental confirmations. Here we present an updated version of inflammaging focused on omics data – particularly on glycomics – collected on centenarians, semi-supercentenarians and their offspring. Accordingly, we arrived to the following conclusions: i) inflammaging has a structure where specific combinations of pro- and anti-inflammatory mediators are involved; ii) inflammaging is systemic and more complex than we previously thought, as many organs, tissues and cell types participate in producing pro- and anti-inflammatory stimuli defined “molecular garbage”; iii) inflammaging is dynamic, can be propagated locally to neighboring cells and systemically from organ to organ by circulating products and microvesicles, and amplified by chronic age-related diseases constituting a “local fire”, which in turn produces additional inflammatory stimuli and molecular garbage; iv) an integrated Systems Medicine approach is urgently needed to let emerge a robust and highly inform...

Source: Mechanisms of Ageing and Development - January 15, 2017 Category: Geriatrics Source Type: research