Cell-selective proteomics for biological discovery.

Cell-selective proteomics for biological discovery.
Curr Opin Chem Biol. 2017 Jan 12;36:50-57
Authors: Stone SE, Glenn WS, Hamblin GD, Tirrell DA
Abstract
Cells alter the proteome to respond to environmental and developmental cues. Global analysis of proteomic responses is of limited value in heterogeneous environments, where there is no 'average' cell. Advances in sequencing, protein labeling, mass spectrometry, and data analysis have fueled recent progress in the investigation of specific subpopulations of cells in complex systems. Here we highlight recently developed chemical tools that enable cell-selective proteomic analysis of complex biological systems, from bacterial pathogens to whole animals.
PMID: 28088696 [PubMed - as supplied by publisher]

Source: Current Opinion in Chemical Biology - January 11, 2017 Category: Biochemistry Authors: Stone SE, Glenn WS, Hamblin GD, Tirrell DA Tags: Curr Opin Chem Biol Source Type: research