What Are Options for Acne Treatment?

Discussion Acne vulgaris or acne is a problem of the pilosebaceous follicle. It occurs most prominently where sebaceous glands are abundant especially the face, neck, and upper back. Sebum production increases because of androgens. Keratin and sebum clog the pores of the pilosebaceous unit causing hyperkeratosis (clogged pilosebaceous unit = clogged pores = comedomes). Propionibacterium acnes, a gram-negative anaerobe, multiplies in the sebaceous unit causing an inflammatory reaction resulting in moderate or severe acne. Skin lesions include: Comedomal acne has comedomes White heads = closed comedomes Black heads = open comedomes Inflammatory acne has papules and pustules Nodulocystic acne has nodules and cysts For each type, the density and extent of the lesions should be noted. Scarring presence or absence should be noted. Any scarring should be treated aggressively. Patients with cystic or scarring acne or who are difficult to treat should be referred to a dermatologist. Some reasons for treatment failures include: Lack of adherence is the most common reason for failure. Discussing with the patient what part(s) of the treatment regiment are not working and why can help adherence. Unrealistic expectations – Need to follow the treatment for at least 2-3 months before effectiveness can be evaluated. Irritation because of drying, itching, burning, etc. Check to make sure that patients are also not using other medications such as astringents, antibacterial soaps, s...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news

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Publication date: Available online 20 May 2019Source: Journal of Geriatric OncologyAuthor(s): Francesco Cuccia, Gianluca Mortellaro, Rosario Mazzola, Alessandra Donofrio, Vito Valenti, Antonella Tripoli, Domenica Matranga, Antonio Lo Casto, Giuseppe Failla, Giuseppe Di Miceli, Giuseppe FerreraAbstractObjectivesTo investigate whether assessment with two geriatric screening tools shows a correlation with clinical outcomes of patients aged 65 years or more, with early-stage Non-Small Cell Lung Cancer (es-NSCLC) treated with hypofractionated stereotactic radiotherapy.MethodsFrom March 2014 to June 2018 we retrospectively eva...
Source: Journal of Geriatric Oncology - Category: Cancer & Oncology Source Type: research
ConclusionIntrathecal (S)-(+)-Ketoprofen caused dose-dependent neurohistopathological changes in rats on days 3 and 7 after injection, suggesting that (S)-(+)-Ketoprofen should not be intrathecally administered.ResumoJustificativa e objetivosA administração intratecal de anti-inflamatórios não esteroides é mais eficaz no tratamento da dor pós-operatória. A Anti-inflamatórios não esteroides, como o (S)-(+)-cetoprofeno, pode ser eficaz em doses intratecais inferiores às parenterais; a segurança pré-clínica relativa à possí...
Source: Brazilian Journal of Anesthesiology - Category: Anesthesiology Source Type: research
Around 300 million individuals are affected by major depressive disorder (MDD) in the world. Despite this high number of affected individuals, more than 50% of patients do not respond to antidepressants approved to treat MDD. Patients with MDD that do not respond to 2 or more first-line antidepressant treatments are considered to have treatment-resistant depression (TRD). Animal models of depression are important tools to better understand the pathophysiology of MDD as well as to help in the development of novel and fast antidepressants for TRD patients. This review will emphasize some discovery strategies for TRD from stu...
Source: Molecular Neuropsychiatry - Category: Neuroscience Source Type: research
This study examined whether spinal CCL1 is associated with fracture-associated postoperative pain via AMPA receptor.We herein discovered that the tibial fracture with orthopedic surgery initiated and maintained chronic postoperative pain along with spinal up-regulation of CCL1/CCR8 expression and phosphorylation of GluA1-containing AMPA receptor. Central CCL1/CCR8 inhibition impaired mechanical and cold allodynia, and phosphorylated GluA1-containing AMPA receptor in the spinal dorsal horn. Intrathecal injection of GluA1-containing AMPA receptor antagonist NASPM alleviated fracture-related postoperative pain. Also, exogenou...
Source: Neuroscience Research - Category: Neuroscience Source Type: research
Publication date: August 2019Source: Developmental Cognitive Neuroscience, Volume 38Author(s): Jonathan Levy, Karen Yirmiya, Abraham Goldstein, Ruth FeldmanAbstractEarly life stress carries long-term negative consequences for children's well-being and maturation of the social brain. Here, we utilize a unique cohort to test its effects on mothers' social brain, targeting mothers' neural empathic response in relation to caregiving and child empathic abilities. Mother-child dyads living in a zone of repeated war-related trauma were followed from early childhood and mother-child behavioral synchrony was repeatedly observed. At...
Source: Developmental Cognitive Neuroscience - Category: Neuroscience Source Type: research
CONCLUSION: Although the limited sample size limits comparisons to larger studies, this initial finding suggests that TM implants may be suitable for immediate placement into failed implant sites. PMID: 31107931 [PubMed - as supplied by publisher]
Source: International Journal of Oral and Maxillofacial Implants - Category: ENT & OMF Tags: Int J Oral Maxillofac Implants Source Type: research
Publication date: Available online 20 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Yalda Vasebi, Reza Khakvar, Mohammad Mehdi Faghihi, Boris A. VinatzerAbstractStrains of Pseudomonas syringae pv. syringae (Pss) were isolated from P. armeniaca in different geographic areas in East Azerbaijan province, Iran, and studied for genetic diversity and host preference. Results of morphological, physiological and biochemical tests showed no differences among strains and syrB gene was determined to be present in all strains by PCR using gene-specific primers. Results of antibiotic assays showed that all strai...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
Earlier this month the Centers for Disease Control and Prevention, in the  Morbidity and Mortality Weekly Report (MMWR), reported that from 2015-2016 deaths from cocaine and psychostimulants (such as methamphetamine, Ritalin, dextroamphetamine) increased 52.4 percent and 33.3 percent respectively. In 2017, the CDC reported a  total  overdose rate of 70,237, and cocaine was involved in 19.8 percent of those deaths while other psychostimulants were involved in 14.7 percent. Opioids, primarily synthetic (fentanyl and fentanyl analogs), were found in 72.7 percent of the cocaine deaths and 50.4 percent ...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
Publication date: July 2019Source: Microchemical Journal, Volume 148Author(s): Viktória Licul-Kucera, Márta Ladányi, Géza Hizsnyik, Gyula Záray, Victor G. MihuczAbstractIn this work, a simple, automated multiresidue method consisting of on-line solid phase extraction coupled to liquid chromatography tandem mass spectrometry has been developed for the determination of three macrolide antibiotic residues – erythromycin, clarithromycin and azithromycin – included in the current Watch List (Decision 2018/840) of Water Framework Directive of the European Union in surface water. Due...
Source: Microchemical Journal - Category: Chemistry Source Type: research
ConclusionsFarming in the forest and poor vectors control are two risk factor of chikungunya infection. Therefore, using anti-mosquito repellent when farming and continuous and coordinated mosquito breeding sites elimination are recommended.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
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