Influence of Ivabradine on the Anticonvulsant Action of Four Classical Antiepileptic Drugs Against Maximal Electroshock-Induced Seizures in Mice.

In conclusion, the enhanced anticonvulsant action of valproate by ivabradine in the mouse maximal electroshock-induced seizure model was pharmacodynamic in nature. A special attention is required when combining ivabradine with phenytoin due to a pharmacokinetic interaction and reduction of the anticonvulsant action of phenytoin in mice. The combinations of ivabradine with carbamazepine and phenobarbital were neutral from a preclinical viewpoint. PMID: 28083847 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/28083847?dopt=Abstract

Source: Neurochemical Research - January 11, 2017 Category: Neuroscience Authors: Sawicka KM, Wawryniuk A, Zwolak A, Daniluk J, Szpringer M, Florek-Luszczki M, Drop B, Zolkowska D, Luszczki JJ Tags: Neurochem Res Source Type: research