Log in to search using one of your social media accounts:

 

Methods to simulate rubbing of topical formulation for in vitro skin permeation studies

Publication date: 15 March 2017 Source:International Journal of Pharmaceutics, Volume 519, Issues 1–2 Author(s): Hiep X. Nguyen, Ashana Puri, Ajay K. Banga Rubbing a topical formulation on skin is generally assumed to enhance drug penetration. The aim of this study was to demonstrate different techniques such as using glass rod, rheometer, and gloved finger for rubbing a 2% salicylic acid gel on skin and investigate their effect on in vitro permeation of salicylic acid through dermatomed porcine ear skin. The studies included evaluation of the gel’s rheological properties, gel distribution on skin surface, in vitro permeability, drug distribution in skin, skin extraction recovery, and mass balance. Rubbing with a gloved finger resulted in a uniform gel layer with a thickness of 49.61±15.33μm on the skin surface. No significant difference between the different test groups was observed in terms of the cumulative amount of drug that permeated in 24h (p> 0.05). Drug levels in stratum corneum, epidermis, and dermis were also analyzed. Rubbing with gloved finger delivered significantly higher amount of drug into the skin layers as compared to other test groups (p< 0.05). Amount of drug extracted from skin was reliably correlated to the actual drug levels in skin (R2 =0.99). Considering drug amounts in different compartments, mass balance ranged from 75.86±2.90% to 80.44±2.99%. Graphical abstract
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research

Related Links:

Officials are concerned Sunday about residents who may have come into contact with two tourists from Europe who have the disease
Source: Health News: CBSNews.com - Category: Consumer Health News Source Type: news
Authors: Finsterer J, Stollberger C PMID: 29679098 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
Authors: Delattre JY PMID: 29678271 [PubMed - in process]
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research
Otto Rank was born. One of Sigmund Freud's closest colleagues in the early days of the psychoanalytic movement and later a pioneering existential psychoanalyst. Rank produced a prolific body of published work covering a range of topics including art, music, creativity, myth and religion. See following link for psychoanalysis information and resources.Psychoanalysis
Source: Forensic Psychology Blog - Category: Forensic Medicine Source Type: blogs
Authors: Veličković J, Palibrk I, Miličić B, Veličković D, Jovanović B, Rakić G, Petrović M, Bumbaširević V Abstract Lactate levels are widely used as an indicator of outcome in critically ill patients. We investigated the prognostic value of postoperative lactate levels for postoperative complications (POC), mortality and length of hospital stay after elective major abdominal surgery. A total of 195 patients were prospectively evaluated. Lactate levels were assessed on admission to the intensive care unit (ICU) [L0], 4 hours (L4), 12 hours (L12), and 24 hours (L24) after the operation. Demographic...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research
Authors: Ahued-Ortega JA, León-García PE, Hernández-Pérez E Abstract BACKGROUND AND OBJECTIVE: Natriuretic peptide type B (BNP) is a marker of myocardium injury. This peptide has been associated with metabolic risk markers, although controversy exists in this regard. The aim of the present study was to determine the correlation of plasma BNP levels with metabolic risk parameters. MATERIALS AND METHODS: A retrospective, observational study that included 152 patients, who were classified according to their clinical diagnosis as patients with metabolic syndrome. Plasma BNP levels and cl...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
Authors: Domagoj M, Branka JZ, Jelena M, Davor M, Duska G Abstract BACKGROUND AND OBJECTIVE: According to recent guidelines, the best approach for treatment of heart failure patients with preserved ejection function is still not defined. The aim of this study was to investigate how carvedilol therapy influences the survival rate, ejection fraction and NYHA class in these patients. PATIENTS AND METHODS: We conducted study on heart failure patients with preserved systolic function from the Croatian heart failure registry who were hospitalized in the period between 2005 and 2010. We enrolled patients with carvedil...
Source: Medicina Clinica - Category: General Medicine Tags: Med Clin (Barc) Source Type: research
The British artist Michael Pinsky invited the public to sample some of the world ’ s most contaminated air by creating globes they could walk through.
Source: NYT Health - Category: Consumer Health News Authors: Tags: London (England) Air Pollution Pinsky, Michael (1967- ) Earth Day Somerset House Beijing (China) New Delhi (India) Sao Paulo (Brazil) Tautra Island (Norway) vis-multimedia Source Type: news
The Pallimed community is invited to participate in the #hpm Tweet Chat this week which help inform and shape a comparative effectiveness research proposal being designed by the Brain Cancer Quality of Life Collaborative, an initiative led by a team of patients, care partners, advocates, neuro-oncologists, and palliative care professionals.The #hpm Tweet Chat is this Wednesday, April 25th, 6-7p PST/9-10p ET.Topics for the chatare available here, in the #hpm chat ’s blog post,How might we introduce palliative care to people with complex neurological conditions, by Liz Salmi and Bethany Kwan, P...
Source: Pallimed: A Hospice and Palliative Medicine Blog - Category: Palliative Care Tags: #hpm brain cancer btsm tweetchat twitter Source Type: blogs
190 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results: "Stud Health Technol Inform"[ta] These pubmed results were generated on 2018/04/22PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Source: Studies in Health Technology and Informatics - Category: Information Technology Tags: Report Source Type: research
More News: Dermatology | Drugs & Pharmacology | Skin | Study