OtoNexus raises $8m for middle-ear infection tech

OtoNexus Medical Technologies raised $7.9 million to fund development of its ultrasound device used to diagnose middle-ear infections in children and determine if antibiotics are needed for treatment. The Seattle-based company sold nearly $8 million in equity of its $9.2 million offering. CEO Caitlin Cameron filed a Form D with the Securities &Exchange Commission, writing that the 1st sale date was December 30, 2016. OtoNexus is developing an air-coupled ultrasound diagnostic device that identifies and characterizes fluid in the middle ear to determine if a physician should prescribe antibiotics. The device uses disposable tips and an interface to display data to the physician in seconds, according to the company. Nearly 93% of American children will suffer a middle ear infection, or otitis media, severe enough to warrant a doctor’s visit, OtoNexus wrote on their website. Current diagnostics are inaccurate, the company argued, and clinical studies show diagnostic error rates averaging 50%. Overdiagnosis of otitis media and overprescription of antibiotics can ultimately suppress the child’s ability to fight infection, predisposing the child to additional cases of otitis media. Antibiotics, which are prescribed in 85% of cases, should be prescribed in 25% cases or less, according to the CDC. In 2015, the White House set a goal to cut the number of unnecessary antibiotic prescriptions in half by 2020, as part of the plan to fight drug-resistant bac...
Source: Mass Device - Category: Medical Equipment Authors: Tags: Funding Roundup Otolaryngology Ear, Nose & Throat Pediatrics Wall Street Beat OtoNexus Medical Technologies Source Type: news

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Raquel Ferrer-Espada1,2, Xiaojing Liu1,2, Xueping Sharon Goh1,2 and Tianhong Dai1,2* 1Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States 2Vaccine &Immunotherapy Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States Polymicrobial biofilms, in which mixed microbial species are present, play a significant role in persistent infections. Furthermore, polymicrobial biofilms promote antibiotic resistance by allowing interspecies transfer of antibiotic resistance genes. In the present study, we investigated the effec...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
CONCLUSION: The results from this study suggest that our NTHi AOM coinfection model is useful for assessing protein vaccines. PMID: 30136923 [PubMed - as supplied by publisher]
Source: Journal of Medical Microbiology - Category: Microbiology Authors: Tags: J Med Microbiol Source Type: research
ConclusionIn our experiment, topically applied KR-12-a2 solution did not cause hearing loss or cochlear damage in guinea pigs. The KR-12-a2 solution can be used as ototopical drops for treating methicillin-resistant staphylococcus aureus otorrhea; however, further evaluations, such as the definition of optimal concentration and combination, are necessary.ResumoIntroduçãoO Staphylococcus aureus resistente à meticilina é um problema emergente não só para a otite média supurativa crônica, mas também para casos de otorreia crônica em crianças com tubo d...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Authors: Tadesse S, Alemayehu H, Tenna A, Tadesse G, Tessema TS, Shibeshi W, Eguale T Abstract BACKGROUND: Staphylococcus aureus is one of the major pathogens of public health importance responsible for various forms of infection. Development of resistance to commonly used antimicrobials limited treatment options against infections due to this pathogen. Antimicrobial resistance profile of Staphylococcus aureus isolated from patients with surgical site infection and ear infection and corresponding nasal swab was investigated in Tikur Anbessa Specialized Hospital (TASH), Addis Ababa, Ethiopia. METHODS: Wound and ...
Source: BMC Pharmacology and Toxicology - Category: Drugs & Pharmacology Tags: BMC Pharmacol Toxicol Source Type: research
Background: Acute otitis media (AOM) nonresponsive to antibiotics is most commonly caused by antibiotic-resistant Streptococcus pneumoniae and Haemophilus influenzae. A strategy for treating these infections with parenteral ceftriaxone was adopted at the Children’s Hospital Iceland. The 10-valent pneumococcal H. influenzae protein D-conjugate vaccine was introduced into the vaccination program in Iceland in 2011. The aim was to study its effect on the incidence of AOM with treatment failure. Methods: This retrospective observational study included children who visited the Children’s Hospital Iceland becaus...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Follow me on Twitter @JohnRossMD Antibiotic resistance is an emerging threat to public health. If the arsenal of effective antibiotics dwindles, treating infection becomes more difficult. Conventional wisdom has long held that stopping a course of antibiotics early may be a major cause of antibiotic resistance. But is this really supported by the evidence? According to a new study in the BMJ, the answer is no. The notion that a longer course of antibiotics prevents resistance started early in the antibiotic era, when doctors found that patients with staphylococcal blood infections and tuberculosis relapsed after short anti...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Infectious diseases Source Type: blogs
Conclusion In our experiment, topically applied KR-12-a2 solution did not cause hearing loss or cochlear damage in guinea pigs. The KR-12-a2 solution can be used as ototopical drops for treating MRSA otorrhea; however, further evaluations, such as the definition of optimal concentration and combination, are necessary.
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Conclusion In our experiment, topically applied KR-12-a2 solution did not cause hearing loss or cochlear damage in guinea pigs. The KR-12-a2 solution can be used as ototopical drops for treating MRSA otorrhea; however, further evaluations, such as the definition of optimal concentration and combination, are necessary.
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
This study evaluated changes over 5 years in principal pathogens and their antibiotic sensitivity in patients in Korea diagnosed with acute OM (AOM) and OM with effusion (OME). The study population consisted of 683 patients who visited the outpatient department of otorhinolaryngology in 7 tertiary hospitals in Korea between January 2010 and May 2015 and were diagnosed with acute AOM or OME. Aural discharge or middle ear fluid were collected from patients in the operating room or outpatient department and subjected to tests of bacterial identification and antibiotic sensitivity. The overall bacteria detection rate of AOM wa...
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
AbstractMicrobial infection is one of the most significant causes of ear diseases, but microbial profiles are very diverse according to the diseases and change over time. The purpose of the study was to clarify differences and chronological changes in causative pathogens among infectious ear diseases over the last 20  years, and to identify antibiotic resistance. In total, 1191 isolates were included from patients diagnosed with chronic otitis media without cholesteatoma (COM), cholesteatomatous otitis media (Chole), middle ear effusion (MEE), including acute otitis media and otitis media with effusion, and ext ernal ...
Source: European Archives of Oto-Rhino-Laryngology - Category: ENT & OMF Source Type: research
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