Nephrectomy induced reduced renal function and the Health ‐related Quality Of Life (HrQOL) of Living Kidney Donors (LKDs)

Abstract ObjectiveTo evaluate the health impact of nephrectomy on LKDs by comparing the HrQOL scores measured by Short Form‐36 (SF36) between those with and without post‐donation renal function impairment (PRFI). Methods82 LKDs (47 females, mean age = 50.2 ± 11.2 years) were prospectively recruited to participate in a SF‐36 HrQOL survey. Chart review, individual baseline and postoperative renal function (eGFR) was determined using the Modification of Diet in Renal Disease (MDRD) formula. PRFI was defined as eGFR
Source: Clinical Transplantation - Category: Transplant Surgery Authors: Tags: Original Article Source Type: research

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Authors: Hill BG, Shiva S, Ballinger S, Zhang J, Darley-Usmar VM Abstract It is now becoming clear that human metabolism is extremely plastic and varies substantially between healthy individuals. Understanding the biochemistry that underlies this physiology will enable personalized clinical interventions related to metabolism. Mitochondrial quality control and the detailed mechanisms of mitochondrial energy generation are central to understanding susceptibility to pathologies associated with aging including cancer, cardiac and neurodegenerative diseases. A precision medicine approach is also needed to evaluate the ...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
Conclusion: The results of this randomised controlled trial with assessment of blood pressure and same-day self-reports will provide patients a tool to understand the interplay between blood pressure and lifestyle applicable to primary health care. The self-management support system may be of importance for improved adherence to treatment and persistence to treatment recommendations. PMID: 31814476 [PubMed - as supplied by publisher]
Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
Authors: Morita K, Wang D, Baba R, Morimoto H, Song Y, Kanazawa T, Yoshida Y Abstract Although it is known that desert dust exacerbates allergic diseases, how it affects the onset of autoimmune diseases is unclear. No epidemiological investigations or animal experiments have been conducted so far to elucidate the effects of desert dust on autoimmune diseases. Here, we focused on particulate matter, such Asian sand dust (ASD) that has been known to cause adverse health effects in East Asian countries, and conducted animal experiments to examine how ASD influences type 1 diabetes (T1D), an autoimmune disease. An ASD ...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
Publication date: Available online 11 December 2019Source: Life SciencesAuthor(s): Qingting Wang, Wenhua Shi, Qianqian Zhang, Wei Feng, Jian Wang, Cui Zhai, Xin Yan, Manxiang LiAbstractAimsIt has been shown that up-regulation of E3 ubiquitin ligase seven-in-absentia-homolog 2 (Siah2) and activation of Hippo signaling pathway effector yes-associated protein (YAP) are involved in the development of pulmonary arterial hypertension (PAH). However, it is still unclear whether Siah2 activates YAP in MCT-induced PAH rat model.Main methodsIntraperitoneal injection of monocrotaline (MCT) was used to induce PAH rat models. The right...
Source: Life Sciences - Category: Biology Source Type: research
In this study, N-methylated peptide inhibitors F-N(Me)H-L, V-N(Me)F-R and R-N(Me)V-Y were synthesized against ACE, NEP and APN respectively, using their respective physiological substrates. F-N(Me)H-L inhibited ACE activity with an IC50 of 83 nmol/L, V-N(Me)F-R inhibited NEP activity with an IC50 of 1.173 μmol/L and R-N(Me)V-Y inhibited APN activity with an IC50 of 3.94 nmol/L respectively. Further, the anti-hypertensive effect of N-methylated peptides was evaluated using rat model of dexamethasone-induced hypertension. Individual peptides and their cocktail treatment were started from day 6 of the ...
Source: Peptides - Category: Biochemistry Source Type: research
A novel endovascular device is a new alternative to surgery for the creation of an arteriovenous fistula for hemodialysis access in those with kidney disease, and has a high level of patient satisfaction.Medscape Medical News
Source: Medscape Transplantation Headlines - Category: Transplant Surgery Tags: Nephrology News Source Type: news
Publication date: Available online 11 December 2019Source: Urology Case ReportsAuthor(s): Mesut Demir, Cumhur Yesildal, Abdullah Hizir Yavuzsan, Sinan Levent Kirecci, Ali Ihsan DokucuAbstract46-year-old wife (donor) and 52-year-old husband (recipient) admitted to our clinic for kidney transplantation. CT angiography of the donor showed us there were bilateral renal double artery and a tortuous aorta that is deviated to the left side. The main artery cannot be reached by laparoscopy because of the upper level of renal artery and deviation of the aorta and an open conversion was performed. Presence of tortuous aorta with mul...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Publication date: Available online 11 December 2019Source: Urology Case ReportsAuthor(s): Nobufumi Ueda, Hirohito Naito, Mikio SugimotoAbstractWe experienced a case of retroperitoneal hematoma secondary to spontaneous lumbar artery rupture in a kidney transplant patient. A 48-year-old woman underwent kidney transplantation for end-stage renal disease. Fifteen days after transplantation, the patient presented with strong abdominal and back pain on the right side, and blood examination showed severe anemia. Contrast-enhanced computed tomography and emergent angiography was performed, which showed extravasation from the lumba...
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Condition:   Bile Acid, Microbiota, Treatment of Diabetes Intervention:   Sponsor:   Chang Gung Memorial Hospital Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Congenital Heart Disease Intervention:   Diagnostic Test: Transesophageal echocardiogram (TEE) Sponsor:   The Hospital for Sick Children Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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