In Depth Life-saving diphtheria drug is running out
Two children have died in Europe in the past 2 years because they suffered from diphtheria and did not get an antiserum that neutralizes the deadly toxin produced by Corynebacterium diphtheriae in time. The antitoxin, produced in horses, is in short supply worldwide; the market is too small to make production profitable. The European Center for Disease Control and Prevention is planning to highlight the shortage in a report expected early in 2017 that will also address Europe's diagnostic capacity for diphtheria. Meanwhile, researchers are trying to make the antitoxin in cell culture, which could help shore up production and improve quality. Author: Kai Kupferschmidt
Authors: Rengganis I Abstract Low adult vaccination coverage in Indonesia may contribute to a recent outbreak of diphtheria in Indonesia. Although well known as a pediatric vaccine, diphtheria vaccination should be administered as booster to adolescence and adults for longer prevention. Adult vaccine differs from pediatric vaccine but have similar protection. Additionally, there is special recommendation to vaccinate pregnant women and elderly people aged 65 years or more. PMID: 30333279 [PubMed - in process]
(University of Washington Health Sciences/UW Medicine) In the ongoing chemical battles among bacteria and their microbial neighbors, a new toxin has been uncovered. This unfamiliar toxin behaves in a familiar way. Its actions against other bacteria resemble the mechanisms of cholera, pertussis and diphtheria toxins. Some bacteria deploying this toxin have safeguards against self-poisoning.
Publication date: Available online 11 October 2018Source: CellAuthor(s): Merav Cohen, Amir Giladi, Anna-Dorothea Gorki, Dikla Gelbard Solodkin, Mor Zada, Anastasiya Hladik, Andras Miklosi, Tomer-Meir Salame, Keren Bahar Halpern, Eyal David, Shalev Itzkovitz, Tibor Harkany, Sylvia Knapp, Ido AmitSummaryLung development and function arises from the interactions between diverse cell types and lineages. Using single-cell RNA sequencing (RNA-seq), we characterize the cellular composition of the lung during development and identify vast dynamics in cell composition and their molecular characteristics. Analyzing 818 ligand-recept...
This report summarizes vaccination coverage and exemption estimates collected by state and local immunization programs* for children in kindergarten (kindergartners) in 49 states and the District of Columbia (DC) and kindergartners provisionally enrolled (attending school without complete vaccination or exemption while completing a catch-up vaccination schedule) or in a grace period (a set interval during which a student may be enrolled and attend school without proof of complete vaccination or exemption) for 28 states. Median vaccination coverage† was 95.1% for the state-required number of doses of diphtheria and t...
We report the results of the 2007 national serological survey of immunity to diphtheria in Australia to assess the impact of recent schedule changes on diphtheria immunity, and the adequacy of current policy in the context of increased international travel of people and pathogens. Residual sera (n =1656) collected opportunistically from Australian laboratories in 2007 were tested for diphtheria antibody levels using an enzyme immunoassay, with the protective threshold defined as ≥0.1 IU/mL. About 40% of adults aged ≥30 years are susceptible to diphtheria; following the removal of the 18 month booster and its replacem...
This prospective cohort study assesses whether maternal immunization with tetanus, diphtheria, and acellular pertussis (Tdap) vaccine, compared with no immunization, is associated with high concentrations of pertussis toxin antibodies at birth and if there is an optimal gestational age for maternal immunization.
Journal of Paediatrics and Child Health, EarlyView.
CONCLUSION: Children in care have consistently lower vaccine coverage than children not in care. Policies and practices should promote optimal access to vaccination for these children. PMID: 30284125 [PubMed - as supplied by publisher]
The United States is working with governments across Latin America to help prevent the spread of diseases like diphtheria and measles from Venezuela as refugees flee the chaotic country, U.S. Health and Human Services Secretary Alex Azar said on Tuesday.