In Depth Life-saving diphtheria drug is running out
Two children have died in Europe in the past 2 years because they suffered from diphtheria and did not get an antiserum that neutralizes the deadly toxin produced by Corynebacterium diphtheriae in time. The antitoxin, produced in horses, is in short supply worldwide; the market is too small to make production profitable. The European Center for Disease Control and Prevention is planning to highlight the shortage in a report expected early in 2017 that will also address Europe's diagnostic capacity for diphtheria. Meanwhile, researchers are trying to make the antitoxin in cell culture, which could help shore up production and improve quality. Author: Kai Kupferschmidt
Conclusions Centralized reminder/recall was effective at increasing influenza vaccination rates in adults aged ≥65 years over a short time period, without burdening the practices, and at a reasonable cost. Trial Registration This study is registered at www.clinicaltrials.gov NCT02133391.
Conclusions Infants of mothers who received prenatal Tdap experienced half the rate of pertussis as compared with infants of unimmunized mothers. These results do not provide evidence to support changing the currently recommended timing of Tdap administration in pregnancy.
ConclusionNot only in Italy, vaccination against diphtheria, tetanus, pertussis, hepatitis B, poliovirus, Haemophilus influenzae type b, measles, mumps, rubella and varicella is mandatory in children under 18 months. Other European countries adopted compulsory policies in order to prevent the spread of infectious diseases and to protect the community.
Conclusions: Primary and booster vaccinations of infants/toddlers with DTPa-HBV-IPV/Hib and PHiD-CV coadministered with MenACWY-TT were immunogenic with clinically acceptable reactogenicity profiles. These results support the coadministration of MenACWY-TT with routine childhood vaccines.
DISCUSSION: Although the MCV wastage rate in our study was in line with national targets, providers reported waiting for more than one child before opening an MCV vial, contrary to vaccine management guidelines. Future research should explore the causal links between provider practices related to vaccine wastage and their impact on vaccination coverage. PMID: 29907485 [PubMed - as supplied by publisher]
CONCLUSIONS: Our study suggests that providers can improve Tdap and influenza vaccination acceptance in pregnancy by recommending the vaccination in combination with provision of educational materials on the vaccines. PMID: 29907484 [PubMed - as supplied by publisher]
Conditions: Tetanus; Diphtheria; Pneumococcal Infections Interventions: Biological: Tetanus-diphtheria (Td) and PCV13; Biological: PCV13 alone; Biological: Td alone Sponsor: Korea University Guro Hospital Completed
No new or unexpected adverse events have been detected for diphtheria-tetanus-acellular pertussis (DTaP) vaccines licensed in the U.S., according to a review of close to 20 years of VAERS data, although vaccination errors may have increased.Reuters Health Information
In this report, we describe two cases of C. diphtheriae infection. The first is a case of cutaneous diphtheria in a Malaysian woman caused by a toxigenic strain of C. diphtheriae. In the second case, a nontoxigenic C. diphtheriae strain was isolated from the blood of a fully vaccinated pediatric patient with underlying congenital heart disease.
In this study, we aimed to investigate the immunogenicity of cationic liposomes loaded with diphtheria toxoid (DT) and poly(I:C) after hollow microneedle-mediated intradermal vaccination in mice. The following liposomal formulations were studied: DT loaded liposomes, a mixture of free DT and poly(I:C)-loaded liposomes, a mixture of DT-loaded liposomes and free poly(I:C), and liposomal formulations with DT and poly(I:C) either individually or co-encapsulated in the liposomes. Reference groups were DT solution adjuvanted with or without poly(I:C) (DT/poly(I:C)). The liposomal formulations were characterized in terms of parti...