In Depth Life-saving diphtheria drug is running out
Two children have died in Europe in the past 2 years because they suffered from diphtheria and did not get an antiserum that neutralizes the deadly toxin produced by Corynebacterium diphtheriae in time. The antitoxin, produced in horses, is in short supply worldwide; the market is too small to make production profitable. The European Center for Disease Control and Prevention is planning to highlight the shortage in a report expected early in 2017 that will also address Europe's diagnostic capacity for diphtheria. Meanwhile, researchers are trying to make the antitoxin in cell culture, which could help shore up production and improve quality. Author: Kai Kupferschmidt
JAKARTA (Reuters) - Health authorities in Jakarta kicked off a special immunization program on Monday to rein in an "extraordinary" outbreak of diphtheria that has sparked concerns about the Indonesian capital ’s readiness to host the Asian Games next June. Diphtheria cases have spiked 42 percent since last year, health officials say, with at least 32 deaths and more than 590 cases recorded across the archipelago, the bulk of them in densely populated Jakarta and neighboring provinces.
Indonesia has begun a campaign to immunize 8 million children and teenagers against diphtheria after the disease killed 38 people, mostly children, since January
JAKARTA (Reuters) - Indonesian health authorities will launch an immunization drive next week to contain a sharp rise in cases of diphtheria, which has killed at least 32 people, including many children, in the world's fourth most populous country this year.
Diphtheria is spreading fast in Cox ’s Bazar
Background: Eosinophils interact directly with airway nerves in patients and mouse models of asthma.Aim: We investigated the effects of eosinophils on airway ganglia number and neurotransmitter expression.Methods: Adult wild-type (WT, C57Bl/6), eosinophil-deficient (PHIL, diphtheria toxin expression driven by the eosinophil peroxidase promoter), and airway eosinophilia mice (NJ1726, IL5 expression driven by the CC10 airway epithelium specific promoter) were studied. Whole mount tracheas were labeled with antibodies against the pan-neuronal marker PGP9.5 and with either: substance P, neuronal nitric oxide synthase (nNOS), o...
CONCLUSION: The study documented a further improvement in full vaccination coverage in Burkina Faso in recent years and better vaccination coverage in rural than in urban areas. The organization of healthcare systems with systematic outreach activities in the rural areas may explain the difference between rural and urban areas. PMID: 29185899 [PubMed - in process]
Hundreds of thousands of Rohingya refugees who fled from Myanmar into Bangladesh are at risk from a possible outbreak of diphtheria, the World Health Organization said in a report published on Tuesday.Reuters Health Information
GENEVA (Reuters) - Hundreds of thousands of Rohingya refugees who fled from Myanmar into Bangladesh are at risk from a possible outbreak of diphtheria, the World Health Organization said in a report published on Tuesday.
is an infection caused by the bacterium Corynebacterium Diphtheriae. Signs and symptoms usually start 2 – 5 days after exposure and range from mild to severe. Symptoms often come on gradually, beginning with a sore throat and fever. In severe cases, the bacteria produces a poison (toxin) that causes a thick grey or white patch at the back of throat. This can block the airway making it hard to b reathe or swallow and also create a barking cough. The neck may swell in part due to enlarged lymph nodes. The poison may also get into the blood stream causing &nb...