People with forms of early-onset Parkinson's disease may benefit from boosting niacin in diet, research suggests

People with certain forms of early-onset Parkinson's disease may benefit from boosting the amount of niacin in their diet, according to new research from the University of Leicester.
Source: Parkinson's Disease News From Medical News Today - Category: Neurology Tags: Parkinson's Disease Source Type: news

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Electrochemical biosensors for the detection and study of α-synuclein related to Parkinson's disease - A review. Anal Chim Acta. 2019 Dec 16;1089:32-39 Authors: Hassan Q, Li S, Ferrag C, Kerman K Abstract Parkinson's disease (PD) is a long-term degenerative disorder that affects predominately dopaminergic neurons in the substantia nigra, which mainly control movement. Alpha-synuclein (α-syn) is a major constituent of Lewy bodies that are reported to be the most important toxic species in the brain of PD patients. In this critical review, we highlight novel electrochemical biosensors that h...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
Discussion and conclusionCrinamine and epibuphanisine exhibited potent and selective inhibitory activity towards MAO-B. After comprehensive in silico investigations encompassing robust molecular docking analysis, the drug-like attributes and safety of the alkaloids suggest the crinamine is a potentially safe drug for human application.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 19 October 2019Source: Stem Cell ResearchAuthor(s): Marija Dulovic-Mahlow, Agnieszka Lukomska, Sokhna Haissatou Diaw, Alexander Balck, Max Borsche, Karen Grütz, Insa Lenz, Franziska Rudolph, Katja Lohmann, Christine Klein, Philip SeiblerAbstractDespite a genetic component in the development of Parkinson´s disease (PD), monozygotic twin pairs often display discordance for PD. Here, we describe the generation of six human induced pluripotent stem cell (iPSC) lines from dermal fibroblasts of three pairs of monozygotic twins discordant for PD. We used non-integrating Sendai virus a...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
Publication date: Available online 20 October 2019Source: Molecular and Cellular NeuroscienceAuthor(s): Navneet Ammal Kaidery, Manuj Ahuja, Bobby ThomasAbstractSearch for a definitive cure for neurodegenerative disorders like Parkinson's disease (PD) has met with little success. Mitochondrial dysfunction and elevated oxidative stress precede characteristic loss of dopamine-producing neurons from the midbrain in PD. The majority of PD cases are classified as sporadic (sPD) with an unknown etiology, whereas mutations in a handful of genes cause monogenic form called familial (fPD). Both sPD and fPD is characterized by protei...
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
Publication date: Available online 18 October 2019Source: Stem Cell ResearchAuthor(s): Ana Joana Duarte, Diogo Ribeiroa, Renato Santos, Luciana Moreira, José Bragança, Olga AmaralAbstractGaucher Disease (GD) type 3 is a neurological form of a multisystemic autosomal recessive disorder belonging to the group of lysosomal storage diseases. Mutations in glucocerebrosidase 1 (GBA1) commonly lead to abnormal protein and GD, heterozygosity is a genetic risk factor for Parkinson's disease. This work describes the use of a non-integrative approach using Sendai Virus delivery to establish iPSCs from fibroblasts from a...
Source: Stem Cell Research - Category: Stem Cells Source Type: research
In this study, the several uses of levodopa electrochemical sensors in areas such as pharmaceutical or clinical evaluation, with levodopa as a vital analyte are reviewed.
Source: Microchemical Journal - Category: Chemistry Source Type: research
AIM: The primary aim of this study was to analyze the frequency and characteristic patterns of fall-related fractures as well as consecutive hospitalization and management relating to such fractures. In addition, important pathognomonic and therapeutic asp...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Depression is a frequent non-motor symptom of Parkinson's disease (PD), and may even precede the onset of motor symptoms of parkinsonism. Beyond its negative influence on mood and affection, depression in PD is frequently associated with other neuropsychia...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Suicide and Self-Harm Source Type: news
Authors: Cabreira V, Massano J Abstract Parkinson's disease is the second most common neurodegenerative disorder, and a significant increase in its prevalence in the past three decades has been documented. Environmental and genetic factors contribute to the pathophysiology of this disease, and 5% - 10% of cases have a monogenic cause. The diagnosis relies on clinical findings, supported by adequate testing. There is no absolute method to diagnose Parkinson's disease in vivo, except for genetic testing in specific circumstances, whose usefulness is limited to a minority of cases. New diagnostic criteria have been re...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Publication date: Available online 16 October 2019Source: Life Sciences in Space ResearchAuthor(s): Francis A. Cucinotta, Eliedonna CacaoABSTRACTFor the first-time we report on predictions on cognitive detriments from galactic cosmic ray (GCR) exposures on long-duration space missions outside the protection of the Earth's magnetosphere and solid body shielding. Estimates are based on a relative risk (RR) model of the fluence response for proton and heavy ion in rodent studies using the widely used novel object recognition (NOR) test, which estimates detriments in recognition or object memory. Our recent meta-analysis showe...
Source: Life Sciences in Space Research - Category: Biology Source Type: research
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