Fibrillin 2 is upregulated in the ascending aorta of patients with bicuspid aortic valve [CONVENTIONAL AORTIC SURGERY]

CONCLUSIONS: BAV patients have an increased FBN (especially FBN2) gene expression level in the ascending aorta, irrespective of dilatation, whereas MMP expression does not change significantly. These results add a new piece of information to the pathophysiology of BAV disease and point to FBN2 as a new molecular player.

Source: European Journal of Cardio-Thoracic Surgery - January 10, 2017 Category: Cardiovascular & Thoracic Surgery Authors: Rueda-Martinez, C., Lamas, O., Mataro, M. J., Robledo-Carmona, J., Sanchez-Espin, G., Moreno-Santos, I., Carrasco-Chinchilla, F., Gallego, P., Such-Martinez, M., de Teresa, E., Jimenez-Navarro, M., Fernandez, B. Tags: CONVENTIONAL AORTIC SURGERY Source Type: research