The Third Signal Cytokine Interleukin 12 Rather Than Immune Checkpoint Inhibitors Contributes to the Functional Restoration of Hepatitis D Virus-Specific T Cells

Conclusions. This investigation of virus-specific T-cell immunity in patients with HDV infection, the largest to date, revealed premature aging of immune cells and impaired T-cell functionality. This could be restored by blocking inhibitory pathways and, in particular, by supplementing with IL-12.

Source: The Journal of Infectious Diseases - January 9, 2017 Category: Infectious Diseases Authors: Schirdewahn, T., Grabowski, J., Owusu Sekyere, S., Bremer, B., Wranke, A., Lunemann, S., Schlaphoff, V., Kirschner, J., Hardtke, S., Manns, M. P., Cornberg, M., Wedemeyer, H., Suneetha, P. V. Tags: PATHOGENESIS AND HOST RESPONSE Source Type: research