Discovering Novel Targets: The Molecular Genetics of Drug Addiction and Related Co-Morbidities (R01)

Funding Opportunity PA-17-120 from the NIH Guide for Grants and Contracts. This FOA encourages applications for research projects that identify, validate and/or functionally characterize loci, genetic variations and haplotypes that are associated with vulnerability to addiction and that potentially inform the likelihood of responsiveness to treatment. Applications that propose to examine intermediate phenotypes or endophenotypes to assess the molecular genetics of drug addiction, addiction vulnerability and/or their associated co-morbidities and how they are related to drug addiction are especially encouraged. Also encouraged are genetic as well as computational and large-scale genomic approaches, which may include but are not limited to linkage, linkage disequilibrium, case-control or family-based studies, and integration of data from other databases that may supplement substance abuse genetics and genomics data. Data may be collected from the general population, special populations, recent admixed populations, and/or animal models. Secondary data analysis of data collected from the general population, special populations, recent admixed populations, and/or animal models is also appropriate for this announcement. Investigators are encouraged to include functional characterization, gene x gene interactions, gene x environment interactions, gene x environment x development interactions, pharmacogenetics, and non-human models, as appropriate.
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding

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Alcohol is the drug of choice for most teenagers and can lead to severe consequences. Alcohol abuse by teenagers not only affects the young people who are drinking, but also impacts the safety of the people they encounter. Luckily, there are signs to look out for, ways to prevent alcohol abuse by teenagers and ways to get help. Stats on Alcohol Abuse by Teenagers Alcohol is the most commonly used and abused drug among youth in the United States, making it a very large problem. Here are some statistics on alcohol abuse by teenagers, provided by the CDC. Excessive drinking is responsible for more than 4,300 deaths among un...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Drinking Teenagers alcohol abuse alcohol treatment alcohol treatment center alcoholism teens Source Type: blogs
Cliffside Malibu does not condone the use of the term “addict” when referring to people suffering from the disorder of addiction. However, we do understand that others still may use the term in order to find information. Many people may find themselves asking the question, “am I an opioid addict?” if they feel as if their use has spiraled out of control. There are many ways to find out if you may have become addicted to opioids, as well as ways to get help and find treatment. How Opioid Addiction Begins Nearly 80% of heroin users started with prescription opioids, which puts prescription drugs and ...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals addiction treatment opioid opioid crisis opioids pharmaceutical addiction pharmaceutical drug abuse treatment Source Type: blogs
The opioid crisis is known as the health crisis surrounding prescription, and nonprescription, opioid drugs. The overdose and death rates of opioids are climbing exponentially and the use of the drug is more rampant now than ever. How Did the Opioid Crisis Begin? In the late 1990s, pharmaceutical companies reassured the medical community that patients would not become addicted to prescription opioid pain relievers, and healthcare providers began to prescribe them at greater rates. Before long, this lead to the medications becoming misused and it became apparent that these medications were indeed highly addictive. However,...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Heroin Addiction Recovery opioid opioid crisis opioids pharmaceutical addiction pharmaceutical drug abuse treatment pharmacists Source Type: blogs
The largest risks that come with using opioids are addiction and overdose. An overdose occurs when the body has received too much of a substance or a combination of substances. An opioid overdose can be fatal, which makes it important for all individuals to know the signs of one and what to do if it happens. What Happens During an Opioid Overdose? Opioid overdose can occur at any time, even if the opioids are being used as directed and as prescribed. Doctors can accidentally over-prescribe medications or the body can have a reaction that wasn’t expected. Opioids are a depressant, meaning they slow down the central n...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction to Pharmaceuticals Heroin Painkiller Substance Abuse drug overdose heroin addiction heroin users opiates opioid opioids prescription drug abuse prescription drug addiction prescription medication Source Type: blogs
Alcohol is everywhere — restaurants, corner liquor stores, bars, college, celebrations, sports events, weddings, the holidays and more. It can seem nearly impossible to escape alcohol since drinking culture is so embedded in American life. Millions of people suffer from alcohol use disorder and aren’t able to maintain acceptable drinking habits, instead, becoming addicted and suffering from a chronic, progressive disease that can ruin their lives. Luckily, it is a treatable disorder, and learning how to quit drinking is possible. Make the Decision to Quit Drinking The most important step in learning how to qui...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Addiction Recovery Alcohol Alcohol Rehab Information Alcoholism alcohol abuse alcohol addiction alcohol dependence alcohol dependency alcohol detox alcohol disorder alcohol treatment binge drinking drinking problem dr Source Type: blogs
On average, 130 Americans die from an opioid overdose every day. The Centers for Disease Control and Prevention (CDC) considers opioid overdose an epidemic in the United States, estimating it responsible for nearly 68 percent of 70,000 drug-related deaths in 2017. Understanding the effects of opioids can prevent opioid overdose, and knowing the opioid overdose signs can save lives. What Are Opioids? Opioids are a class of drugs naturally found in the opium poppy plant. Opioid drugs reduce pain by binding to opioid receptors in your brain, spinal cord and other areas of the body, creating morphine-like effects. The CDC ide...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Addiction Heroin Painkiller Substance Abuse drug overdose opiate opiate abuse opiate addiction opiates opioid opioids Source Type: blogs
Conclusions: Smoking and substance abuse are common among industrial workers. Tramadol and cannabis are the most commonly abused substances. Smoking, older age, and male sex are correlates of substance abuse. Alcohol abuse is associated with dependence.
Source: Addictive Disorders and Their Treatment - Category: Addiction Tags: Original Articles Source Type: research
We present a brief review on a novel neuromodulation target of the nucleus accumbens (NA) and its promising role in the management of addiction. The three stages of the addiction cycle are known to be mediated by dopaminergic pathways located in the mesolimbic dopamine system with connections to dorsal striatum, extended amygdala, cingulate gyrus, orbitofrontal cortex, prefrontal cortex, and ventral tegmental area. Recent advanced neuroimaging in humans and several animal studies demonstrated NA to be a vital anatomical area modulating this network. DBS of NA in animals reduced addictive behavior to alcohol, cocaine, and o...
Source: Neurology India - Category: Neurology Authors: Source Type: research
Abstract Addiction in patients with cancer is not well described. Patients with substance use disorders (SUDs) and cancer experience worse outcomes; however, no guidelines exist for identifying and successfully managing these issues in oncology. With the goal to improve patient safety and outcomes, an interprofessional work group at a major academic cancer hospital initiated a trial screening process for identifying substance abuse issues in an oncology population. Simultaneously, guidelines for patients with cancer and SUDs were created. PMID: 31730608 [PubMed - in process]
Source: Clinical Journal of Oncology Nursing - Category: Nursing Authors: Tags: Clin J Oncol Nurs Source Type: research
While recreational marijuana is legal in 11 states as of November 2019, more states gravitating toward legalizing the recreational use of the substance, and 33 states allowing medical marijuana, there’s apparently no stopping this trend. Cannabis, in the form of marijuana, hemp, and cannabidiol (CBD)  is being used for pain relief, to alleviate stress, cope with anxiety, and a number of other mental health disorders and addictions. Yet, there’s a dearth of clinical studies that have been conducted on the overall effects on a user’s health. Clearly, as Crain’s Detroit Business points out, more ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Medications Substance Abuse Cannabis Marijuana Source Type: blogs
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