Enzyme Revealed as Promising Target to Treat Asthma and Cancer - 4/10/14

In experiments with mice, Johns Hopkins Kimmel Cancer Center scientists have identified an enzyme involved in the regulation of immune system T cells that could be a useful target in treating asthma and boosting the effects of certain cancer therapies.
Source: Johns Hopkins Medicine News - Category: Research Source Type: news

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This article will summarize the structure and cellular function of MARCKS (also including MARCKS family proteins and MARCKS-like proteins 1 [MARCKSL1]). Evidence for MARCKS' role in several lung diseases, and the technological innovations that took MARCKS-targeting strategies from theoretical to therapeutic, will be discussed. Descriptions and updates from ongoing clinical trials that are investigating inhalation of a MARCKS-targeting peptide as therapy for patients with chronic bronchitis, lung cancer and ARDS will be provided. PMID: 30339463 [PubMed - as supplied by publisher]
Source: American Journal of Respiratory Cell and Molecular Biology - Category: Molecular Biology Authors: Tags: Am J Respir Cell Mol Biol Source Type: research
Abstract Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are often fatal and widely prevalent. The susceptibility of nucleic acids to degradation and the complex structure of lungs retard the effective pulmonary delivery of nucleic acid drug. To overcome these barriers, different strategies have been exploited to increase the delivery efficiency using chemically synthesized nucleic acids, vector encapsulation, proper formulation, and administration route. However, several limitations regarding off...
Source: AAPS PharmSciTech - Category: Drugs & Pharmacology Authors: Tags: AAPS PharmSciTech Source Type: research
Publication date: Available online 15 October 2018Source: Forensic Science International: GeneticsAuthor(s): Cedric Bradbury, Anna Köttgen, Fabian StaubachAbstractWith recent advances in DNA sequencing technologies it has become feasible and cost effective to genotype larger marker sets for forensic purposes. Two technologies that make use of the larger marker sets have come into focus in forensic research and applications; inference of biogeographic ancestry (BGA) and forensic DNA phenotyping (FDP). These methods hold the promise to reveal information about a yet unknown perpetrator from a DNA sample. In contrast, DN...
Source: Forensic Science International: Genetics - Category: Forensic Medicine Source Type: research
(Natural News) At this point, there is no longer any doubt that the pesticides used on a massive scale in conventional farming are harmful to humans, animals and the environment. Exposure to pesticides has been linked to Parkinson’s disease, cancer, reproductive issues, diabetes, autism, asthma and Alzheimer’s disease in humans. Millions of birds and fish...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
th JA Abstract BACKGROUND: Cough is common in patients with lung cancer and current antitussive treatments are suboptimal. There is little published data describing cough in patients with lung cancer or work assessing clinical associations; the aim of the current is study is to fill that gap. METHODS: Longitudinal prospective observational single-cohort study over 60 days. Patients were assessed through self-reported validated scales and, in a subsample, ambulatory cough monitoring, at study entry (day 0), day 30 and day 60. RESULTS: At study entry, 177 patients were included and 153 provided data at day...
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Publication date: Available online 9 October 2018Source: Pharmacological ResearchAuthor(s): D. Visca, P. Pignatti, A. Spanevello, E. Lucini, E. La RoccaAbstractDiabetes is a common metabolic disorder affecting the entire body with high morbidity and mortality worldwide. The major complications related to diabetes are mostly due to the macrovascular and microvascular bed impairment due to metabolic, hemodynamic and inflammatory factors. However, studies over the past decades have added also the lung as a target organ in both type 1 and type 2 diabetes. Diabetes has always been addressed as a major comorbidity conditioning t...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
In this study, we demonstrate that although androgen (dihydrotestosterone) reconstitution of castrated mice reduced lung inflammation in a mouse model of allergic lung inflammation, it enhanced M2 polarization of AM. This indicates a cell-specific role for androgens. Dihydrotestosterone also enhanced IL-4-stimulated M2 macrophage polarization in vitro. Using mice lacking androgen receptor (AR) in monocytes/macrophages (ARfloxLysMCre), we found that male but not female mice exhibited less eosinophil recruitment and lung inflammation due to impaired M2 polarization. There was a reduction in eosinophil-recruiting chemokines a...
Source: Journal of Immunology - Category: Allergy & Immunology Authors: Tags: J Immunol Source Type: research
Abstract Bisphenol A (BPA) is primarily used in production of polycarbonate plastics and epoxy resins including plastic containers. BPA is an endocrine disruptor and supposes to induce asthma and cancer. However, so far only a few evidences have shown the BPA-induced toxic effect and its related mechanism in macrophages. BPA demonstrated cytotoxic effect on RAW264.7 macrophages in a concentration and time-dependent manner. BPA induces necrosis, apoptosis, and genotoxicity in a concentration-dependent manner. Phosphorylation of cytochrome C (cyto C) and p53 was due to mitochondrial disruption via BCL2 and BCL-XL do...
Source: Food and Chemical Toxicology - Category: Food Science Authors: Tags: Food Chem Toxicol Source Type: research
AbstractAirborne particulate matter (PM) that is a heterogeneous mixture of particles with a variety of chemical components and physical features acts as a potential risk to human health. The ability to pose health risk depends upon the size, concentration and chemical composition of the suspended particles. Potential toxic elements (PTEs) associated with PM have multiple sources of origin, and each source has the ability to generate multiple particulate PTEs. In urban areas, automobile, industrial emissions, construction and demolition activities are the major anthropogenic sources of pollution. Fine particles associated ...
Source: Environmental Geochemistry and Health - Category: Environmental Health Source Type: research
Publication date: Available online 5 October 2018Source: Journal of Molecular Graphics and ModellingAuthor(s): Tarek Kanan, Duaa Kanan, Ismail Erol, Samira Yazdi, Matthias Stein, Serdar DurdagiAbstractNuclear factor-κB (NF-κB) transcription factors represent a conserved family of proteins that regulate not only immune cells, but also heart cells, glial cells and neurons, playing a fundamental role in various cellular processes. Due to its dysregulation in certain cancer types as well as in chronic inflammation and autoimmune diseases, it has recently been appreciated as an important therapeutic target. The aim ...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
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