Creation of an intensive care unit and organizational changes in an adult emergency department: impact on acute stroke management
Following the reorganization of a University Medical Center onto a single campus, an Intensive Care Unit was created within the adult Emergency Department (ED ICU). We assessed the effects of these organizational changes on acute stroke management and the intravenous administration of recombinant tissue plasminogen activator (IV rtPA), as characterized by the thrombolysis rate, door-to-needle time (DNT) and outcome at 3 months.
Differential roles of Scavenger receptor class B type I: A protective molecule and a facilitator of atherosclerosis (Review). Mol Med Rep. 2020 Jul 28;: Authors: Ma B, Jia J, Wang X, Zhang R, Niu S, Ni L, Di X, Liu C Abstract The scavenger receptor class B type I (SR‑BI) is a multi‑ligand membrane protein receptor that binds to high‑density lipoprotein (HDL) under physiological conditions, promoting the selective uptake of cholesterol esters from HDL into cells. SR‑BI also promotes the reverse transport of excess cholesterol from peripheral tissues to the liver, contributing to t...
Long non‑coding RNA SNHG16 inhibits the oxygen‑glucose deprivation and reoxygenation‑induced apoptosis in human brain microvascular endothelial cells by regulating miR‑15a‑5p/bcl‑2. Mol Med Rep. 2020 Jul 29;: Authors: Teng H, Li M, Qian L, Yang H, Pang M Abstract MicroRNA (miR) 15a‑5p can promote ischemia/reperfusion (I/R)‑induced apoptosis of cerebral vascular endothelial cells, which is inhibited by long non‑coding RNAs (lncRNAs). The present study investigated the potential of lncRNAs targeting miR‑15a‑5p to regulate oxygen‑glucose deprivation and reoxygenation (OGD‑R)‑in...
Propofol protects against oxygen/glucose deprivation‑induced cell injury via gap junction inhibition in astrocytes. Mol Med Rep. 2020 Jul 28;: Authors: Fan Y, Zhu S, Wang J, Zhao Y, Wang X Abstract Stroke is one of the leading causes of mortality and disability worldwide with limited clinical therapies available. The present study isolated primary astrocytes from the brains of rats and treated them with oxygen‑glucose deprivation and re‑oxygenation (OGD/R) to mimic hypoxia/reperfusion (H/R) injury in vitro to investigate stroke. It was revealed that propofol (2,6‑diisopropylphenol), an int...
In conclusion, MCM3AP‑AS1, LINC01089, ITPK1‑AS1, and HCG27 may represent new biomarkers and underlying targets for the treatment of AIS. PMID: 32945445 [PubMed - as supplied by publisher]
Conclusions: The two-staged procedure for the repair of chronic type A dissection with small true lumen at the descending aorta is adaptable with low prevalence of mortality and complication. PMID: 32944324 [PubMed]
Conclusions: Although emergent total arch replacement for acute type A dissection is a complex scenario, surgeons well-trained in adult cardiac surgery are able to achieve acceptable results in their start-up period. PMID: 32944318 [PubMed]
Conclusions: Our strategy had got low mortality and excellent mid-term survival in patients with type A IMH. Therefore, our strategy was suitable for the surgical repair of type A IMH in Chinese population. PMID: 32944308 [PubMed]
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Condition: Stroke Interventions: Combination Product: Bilateral Arm Training; Combination Product: modified constrained induce movement therapy Sponsor: Riphah International University Completed
Publication date: Available online 19 September 2020Source: Neurología (English Edition)Author(s): J.M. Ramírez-Moreno, S. Bartolomé Alberca, P. Muñoz Vega, E.J. Guerrero Barona