Writer, 38, whose jaw expanded in size because of a rare condition made famous by a James Bond villain reveals how he could die at any minute from stress

Up to 8,300 people in the UK, including Mike Scalise, have acromegaly - where the body produces too much growth hormone - but it often isn't diagnosed until patients are in their 40s.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

Related Links:

Conditions:   Acromegaly;   Muscle Dysfunction;   Physical Activity;   Exercise Intervention:   Procedure: Physical activity Sponsors:   Centro Universitário Augusto Motta;   Rio de Janeiro State Research Supporting Foundation (FAPERJ);   Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Acromegaly is a rare endocrine disorder that carries a significant burden of cardiovascular morbidity and mortality. Abnormalities of the growth hormone/insulin-like growth factor-1 axis in acromegaly lead to the characteristic cardiovascular manifestations of this disease. One hallmark feature of the disease is acromegalic cardiomyopathy, a syndrome of progressive cardiac dysfunction characterized by left ventricular hypertrophy, diastolic dysfunction, and combined systolic and diastolic dysfunction in the very advanced stage. In this article, we review the current concepts regarding the pathophysiology of acromegalic car...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Exp Clin Endocrinol Diabetes DOI: 10.1055/a-0600-9649 Background Although diabetes is a common complication of acromegaly or Cushing´s disease, there are only few detailed studies with a focus on cardiovascular risk, metabolic control or diabetes therapy. Here, we provide a comprehensive characterization from the longitudinal DPV (Diabetes Patienten Verlaufsdokumentation) registry. Methods Patients from the registry≥18 years of age with diabetes and acromegaly or Cushing´s disease were compared to patients with type 1 diabetes or type 2 diabetes using the statistical software SAS 9.4. Results Patients with d...
Source: Experimental and Clinical Endocrinology and Diabetes - Category: Endocrinology Authors: Tags: Original Research Source Type: research
Source: Endocrine - Category: Endocrinology Source Type: research
ConclusionsIn the real-life scenario ~54% of patients with acromegaly resistant to first-generation SSA, may normalize IGF-1 with pasireotide; however, 63% experienced glucose control deterioration.
Source: Endocrine - Category: Endocrinology Source Type: research
ConclusionSleep apnea is common among patients with acromegaly, and is often diagnosed prior to their acromegaly diagnosis. These results support early screening for sleep apnea in patients with acromegaly and awareness for acromegaly in patients with sleep apnea.
Source: Endocrine - Category: Endocrinology Source Type: research
CONCLUSIONS: We will focus on the issues regarding the measurement and interpretation of IGF-I concentrations in the management of acromegaly patients. PMID: 30311754 [PubMed - as supplied by publisher]
Source: Minerva Endocrinologica - Category: Endocrinology Tags: Minerva Endocrinol Source Type: research
Authors: Yuen KC, Popovic V Abstract Previous studies have implicated the growth hormone (GH)/IGF-I axis as an important mediator of cancer risk in humans and animals. Evidence supporting this notion is derived from animal studies, epidemiological observations, patients with acromegaly and from therapeutic manipulation of GH and IGF-I actions. Therefore, the use of GH therapy in patients with a history of malignancy raises hypothetical safety concerns. Reassuringly, GH therapy in childhood cancer survivors has not been confirmed to increase the cancer risk. Conversely, the risk of occurrence of a second neoplasm ma...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Authors: Claessen KM, Pereira AM, Biermasz NR Abstract Acromegaly patients suffer from pathologically high growth hormone (GH) and IGF-1 levels that in 99% of cases is due to a GH-producing pituitary adenoma. During active disease, GH excess is associated with a number of pathological conditions, such as hypertension, hypertrophic cardiomyopathy, sleep apnea, arthropathy, vertebral fractures and insulin resistance. After adequate treatment in the form of transsphenoidal surgery, radiotherapy, medical treatment or by a combination of these treatment modalities, several comorbid conditions improve considerably. Howev...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
Publication date: Available online 12 October 2018Source: Academic RadiologyAuthor(s): Zongming Wang, Zhigang Mao, Xiangsong Zhang, Dongsheng He, Xin Wang, Qiu Du, Zheng Xiao, Diming Zhu, Yonghong Zhu, Haijun WangRationale and ObjectivesIt is clinically essential, but sometimes challenging, to distinguish pituitary tissue from pituitary adenomas (PAs). It is helpful to avoid damage of pituitary tissue during management. We evaluated the ability of 13N-ammonia positron emission tomography (PET)/computed tomography (CT) to locate and distinguish pituitary tissue from PAs.Materials and MethodsForty-eight patients (four with p...
Source: Academic Radiology - Category: Radiology Source Type: research
More News: Acromegaly | Health | Hormones