Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events

Conclusion
These findings demonstrate that TLR7 is abundantly expressed in human atherosclerotic plaques. TLR7 ligation elicits the secretion of pro-inflammatory and anti-inflammatory cytokines, and high TLR7 expression in plaques is associated with better patient outcome, suggesting that TLR7 is a potential therapeutic target for prevention of complications of atherosclerosis.

Source: Cardiovascular Research - January 8, 2017 Category: Cardiology Authors: Karadimou, G., Folkersen, L., Berg, M., Perisic, L., Discacciati, A., Roy, J., Hansson, G. K., Persson, J., Paulsson-Berne, G. Tags: Integrative physiology and pathophysiology Source Type: research