Three new monoterpene glycosides from Sibiraea laevigata (L.) Maxim

Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Jian-Qiang Zhao, Yan-Ming Wang, Qi-Lan Wang, Yun Shao, Yan-Ping Shi, Li-Juan Mei, Yan-Duo Tao Three new compounds, 3,7-dimethy-7-methoxy-3-octene-5-one-1-O-β-d-glucopyranoside (1), 3,7-dimethy-7-methoxy-3(Z)-octene-5-one-1-O-β-d-glucopyranoside (2) and 3,7-dimethy-3-hydroxy-6-octene-5-one-1-O-β-d-glucopyranoside (3), together with fourteen known compounds (4–17) were isolated from the leaves and shoots of S. laevigata. The structures of the new compounds were elucidated on the basis of extensive spectroscopic analysis, including one- and two-dimensional NMR, as well as mass spectral data. All isolates were evaluated for their α-glucosidase inhibitory and antioxidant activities. The results demonstrated that 3,7-dimethyl-3(Z),6-ocatdien-5-one-1-O-β-d-glucoside (7) and sitosteryl β-d-glucoside (17) exhibited α-glucosidase inhibitory effects with IC50 values of 220.0 and 113.0μM, respectively. Graphical abstract

Source: Phytochemistry Letters - January 8, 2017 Category: Chemistry Source Type: research