Novel regulator of key gene expression in cancer identified

A key genetic switch linked to the development, progression and outcome of cancer has been discovered by scientists, a finding that may lead to new targets for cancer therapies. The switch, a string of nucleotides dubbed a long non-coding RNA (lncRNA), does not code for proteins like regular RNA. Instead, the scientists found, this particular lncRNA acts as an on/off switch for a key gene whose excessive activity is tied to inflammation and cancer, COX-2.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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This study suggests that the U11-DOX/CUR NPs have promising potential for combination treatment of lung cancer.Graphical abstract
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
Authors: Mousavi SM, Soroshni S, Hashemi SA, Babapoor A, Ghasemi Y, Mohammad Amani A Abstract At this article, graphene oxide Nano ribbons (GONRs) and its high potential for using in medical fields have been reviewed. Recently, Graphene Nano ribbons (GNRs) has been a field of interest in biological methods and disease treatment such as drug delivery, DNA applications, and photothermal cancer therapies. GNRs demonstrate more efficient properties rather than other graphene-based Nanomaterials due to their larger surface area. These novel properties made them into a remarkable substitute material for biological fields...
Source: Drug Metabolism Reviews - Category: Drugs & Pharmacology Tags: Drug Metab Rev Source Type: research
Funding Opportunity PAR-19-194 from the NIH Guide for Grants and Contracts. The overall purpose of this funding opportunity announcement (FOA) is to stimulate the development of novel microbial-based cancer therapies, especially for conditions where conventional cancer therapies are inadequate, such as poorly vascularized, hypoxic, solid tumors, dormant or slowly dividing cells resistant to current interventions, and brain tumors. Utilizing bacteria, archaebacteria, bacteriophages and other non-virus microorganisms, this initiative will support research projects designed to study the underlying mechanisms of the complex i...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Funding Opportunity PAR-19-193 from the NIH Guide for Grants and Contracts. The overall purpose of this funding opportunity announcement (FOA) is to stimulate the development of novel microbial-based cancer therapies, especially for conditions where conventional cancer therapies are inadequate, such as poorly vascularized, hypoxic, solid tumors, dormant or slowly dividing cells resistant to current interventions, and brain tumors. Utilizing bacteria, archaebacteria, bacteriophages and other non-virus microorganisms, this initiative will support research projects designed to study the underlying mechanisms of the complex i...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
Conclusion: Nature-inspired algorithms and many of combinatorial algorithms are recently proposed to overcome the problems of consensus and probabilistic approaches. This paper presents a general classification of motif discovery algorithms with new sub-categories. It also presents a summary comparison between them.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
Colon cancer is one of the most common and most diagnosed types of cancer. It is a major cause of increased rate of morbidity and mortality across the globe. Currently, the focus has been shifted towards natural remedies for the treatment of colon cancer. These new methods of treatment include prebiotics and probiotics, as they offer great potential for alleviating symptoms of cancer. These are more promising and have lesser side effects than existing medications. Probiotics are living organisms which confer health benefits when ingested into adequate amounts. Prebiotics are non-digestible ingredients which promote the gro...
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
Conclusion: Current review has been highlighted on the novel medicinal agents from plant sources have potential effects against many types of cancer, which have been supported by clinical trials. The main findings of these active novel medicinal agents were also summarized and discussed here.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
Conclusion: Maintenance therapy in NSCLC continues to be an important therapeutic line to improve outcome in patients with metastatic and recurrent disease.
Source: Current Cancer Therapy Reviews - Category: Cancer & Oncology Source Type: research
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