Sudden Death in the Young (SDY) Registry

Funding Opportunity Number: CDC-RFA-DP14-1403 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCFDA Number: 93.946Eligible Applicants State governmentsOthers (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name: HHS-CDC-NCCDPHPClosing Date: Jun 30, 2014Award Ceiling: $200,000Expected Number of Awards: 14Creation Date: May 01, 2014Funding Opportunity Description: SDY has a devastating impact on families, care providers, and the community, and attracts significant public and media attention. The most common diagnoses that increase risk for SDY include hypertrophic cardiomyopathy, coronary artery anomalies of wrong sinus origin, arrhythmogenic right ventricular cardiomyopathy, ion channelopathies, and genetic forms of epilepsy such as Dravet Syndrome. In up to 30% of cases of SCDY no specific diagnosis is found (autopsy negative). Sudden cardiac death has been documented at all ages and may be associated with competitive athletics. Approximately 10-15% of Sudden Infant Death Syndrome (SIDS) cases may be due to ion channelopathies. Similarly, SUDEP has been documented at all ages, and several risk factors have been identified, including some cases originating with ion channelopathies. Rational policy development in the area of screening and prevention is currently limited by the lack of prospectively defined epidemiological data, including incid...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding

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Conclusions This study demonstrates that high-intensity, long-term physical training regimens are feasible in GBM patients during full multidisciplinary therapy. In this patient, the exercise was pursued without adverse events and led to a gain of fitness despite tumor progression and intensive multiple therapies. We conclude that, in GBM patients, exercise regimens require further study instead of general discouragement.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
Conclusions In 10-km road races, injury rates are low compared with longer races in similar weather conditions. Common medical issues can be managed with basic resources in the on-site medical tent. Green flag start race conditions may not predict race safety with regard to exertional heat stroke risk. There were no deaths in nearly 100,000 finishers.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: CLINICAL SCIENCES Source Type: research
We report a case, describe the surgical techniques used, and propose an algorithm for managing the treatment of a young patient who presents with bilateral posterior dislocations related to a seizure. At her most recent follow-up (57 mo postoperative for the left shoulder and 41 mo postoperative for the right shoulder), she denied any apprehension or instability in either shoulder and had no further dislocations. She reported mild chronic pain in both shoulders, worse in the right than the left. She has a smooth passive range of motion with no crepitus in either shoulder. Her range of motion in forward elevat...
Source: Techniques in Shoulder and Elbow Surgery - Category: Orthopaedics Tags: Techniques Source Type: research
Sickle cell disease (SCD) is the most commonly inherited genetic blood disorder, affecting nearly 100,000 children and adults in the United States. Three million Americans carry the sickle cell trait and it is nearly25 times more common in people of African American descent. The disorder, which can cause irregularly shaped blood cells to get stuck in narrow vessels, inflicts substantial pain on patients. The resulting reduced oxygen flow creates life-threatening complications such as difficulty breathing, chest pains, blood clots and stroke.
Source: The Catalyst - Category: Pharmaceuticals Authors: Tags: Research and Development Rare Diseases Pelosi Plan Source Type: news
Matthew O'Conner presented at Undoing Aging earlier this year on the startup biotech company Underdog Pharmaceuticals. The company is spinning out of the SENS Research Foundation (SRF), based on research conducted by the scientific team there in recent years. The company is focused on a class of molecule known cyclodextrins, and have candidates capable of efficiently binding and sequestering 7-ketocholesterol. This form of oxidized cholesterol is of great importance to the progression of atherosclerosis, and possibly other age-related conditions as well. In the case of atherosclerosis, the presence of oxidized cholesterols...
Source: Fight Aging! - Category: Research Authors: Tags: Healthy Life Extension Community Source Type: blogs
Authors: Sharma AA, Szaflarski JP Abstract [Box: see text]. PMID: 31718335 [PubMed]
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
Authors: Maguire JL Abstract [Box: see text]. PMID: 31718334 [PubMed]
Source: Epilepsy Currents - Category: Neurology Tags: Epilepsy Curr Source Type: research
Publication date: Available online 14 November 2019Source: Nutrition, Metabolism and Cardiovascular DiseasesAuthor(s): Zhengbao Zhu, Aili Wang, Daoxia Guo, Xiaoqing Bu, Tan Xu, Chongke Zhong, Yanbo Peng, Tian Xu, Hao Peng, Jing Chen, Zhong Ju, Deqin Geng, Jiang He, Yonghong ZhangBackground and AimsHigh serum hepatocyte growth factor (HGF) levels increase the risk of ischemic stroke and are probably associated with outcomes after ischemic stroke. However, it remains unclear whether the association between HGF and ischemic stroke prognosis is modified by blood lipid status.Methods and ResultsData were derived from the CATIS ...
Source: Nutrition, Metabolism and Cardiovascular Diseases - Category: Nutrition Source Type: research
Publication date: Available online 14 November 2019Source: The Lancet NeurologyAuthor(s): Stephan Arnold
Source: The Lancet Neurology - Category: Neurology Source Type: research
This study is registered with ClinicalTrials.gov, number NCT01866111.FindingsBetween July 31, 2013, and June 22, 2015, 437 patients were randomly assigned to either placebo (n=108) or cenobamate 100 mg (n=108), 200 mg (n=110), or 400 mg (n=111). Of these patients, 434 (106 [98%] in placebo group, 108 [100%] in 100 mg group, 109 [99%] in 200 mg group, and 111 [100%] in 400 mg group) were included in the modified intention-to-treat population, and 397 (102 [94%] in placebo group, 102 [94%] in 100 mg group, 98 [89%] in 200 mg group, and 95 [86%] in 400 mg group) were included in the modified intention-to-treat maintenance pha...
Source: The Lancet Neurology - Category: Neurology Source Type: research
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