Caffeine protects against experimental acute pancreatitis by inhibition of inositol 1,4,5-trisphosphate receptor-mediated Ca2+ release

Conclusions Caffeine and its dimethylxanthine metabolites reduced pathological IP3R-mediated pancreatic acinar Ca2+ signals but only caffeine ameliorated experimental AP. Caffeine is a suitable starting point for medicinal chemistry.

http://gut.bmj.com/cgi/content/short/66/2/301?rss=1

Source: Gut - January 5, 2017 Category: Gastroenterology Authors: Huang, W., Cane, M. C., Mukherjee, R., Szatmary, P., Zhang, X., Elliott, V., Ouyang, Y., Chvanov, M., Latawiec, D., Wen, L., Booth, D. M., Haynes, A. C., Petersen, O. H., Tepikin, A. V., Criddle, D. N., Sutton, R. Tags: Pancreas and biliary tract, Pancreatitis, Open access Source Type: research