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Duke University finds breakthrough for cancer victim infertility after chemotherapy

A breakthrough for cancer victims could prevent women becoming infertile after chemotherapy.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news

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Authors: Nappi L, Ottaviano M, Rescigno P, Fazli L, Gleave ME, Damiano V, De Placido S, Palmieri G Abstract Background: Cisplatin-based chemotherapy significantly improved the survival of patients with germ cell testicular cancer. However, long term side effects of chemotherapy have non-negligible impact on the quality of life of these young patients, who have a long life expectancy after being successfully treated. Materials and Methods: 25-OH vitamin D, testosterone, FSH and LH of patients with testicular cancer were retrospectively evaluated and for each patient clinical information were collected. The tissu...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Sofoudis C, Zervomanolakis I, Galani I, Grigoriou V, Botsis D, Vlahos N Abstract The incidence of young women diagnosed with cancer has been globally increasing. In many cases the surgical approach followed by chemotherapy, radiotherapy or hormonal therapy could lead to infertility or premature ovarian failure. Several options are available in order to preserve fertility and increase the future gestation rate. Among embryo cryopreservation and oocyte cryopreservation, ovarian tissue cryopreservation represents an ideal option, especially for premenopausal women and for those who cannot delay the start of c...
Source: Clinical and Experimental Obstetrics and Gynecology - Category: OBGYN Tags: Clin Exp Obstet Gynecol Source Type: research
Authors: Fung C, Dinh P, Ardeshir-Rouhani-Fard S, Schaffer K, Fossa SD, Travis LB Abstract Testicular cancer has become the paradigm of adult-onset cancer survivorship, due to the young age at diagnosis and 10-year relative survival of 95%. This clinical review presents the current status of various treatment-related complications experienced by long-term testicular cancer survivors (TCS) free of disease for 5 or more years after primary treatment. Cardiovascular disease and second malignant neoplasms represent the most common potentially life-threatening late effects. Other long-term adverse outcomes include neuro...
Source: Advances in Urology - Category: Urology & Nephrology Tags: Adv Urol Source Type: research
Abstract Purpose To provide current recommendations about fertility preservation for adults and children with cancer. Methods A systematic review of the literature published from January 2013 to March 2017 was completed using PubMed and the Cochrane Library. An Update Panel reviewed the identified publications. Results There were 61 publications identified and reviewed. None of these publications prompted a significant change in the 2013 recommendations. Recommendations Health care providers should initiate the discussion on the possibility of infertility with patients with cancer treated during their reproductive...
Source: Clinical Breast Cancer - Category: Cancer & Oncology Authors: Tags: J Clin Oncol Source Type: research
Testis cancer presents a unique problem in male fertility preservation. As many as 50-70% of patients diagnosed with testis cancer are subfertile at the time of diagnosis and up to 15% are azoospermic. Many patients will also require adjuvant radiotherapy or chemotherapy further complicating future fertility potential. In this video, we aim to provide a step-by-step guide to the performance of microsurgical onco-testicular sperm extraction (onco-TESE) in the setting of radical orchiectomy for testis cancer in an azoospermic patient.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: ED, Infertility & Male Incontinence Source Type: research
Due to recent advances in medical technologies, cancer has become more curable and chronic, and post-treatment quality of life, including male fertility, has become an important issue. Semen cryopreservation is generally recommended for patients who will receive cancer chemotherapy. We have retrospectively reviewed the usage rate of cryopreserved semen samples for cancer patients in our institution.
Source: The Journal of Urology - Category: Urology & Nephrology Authors: Tags: Infertility: Therapy II Source Type: research
This study aims to evaluate whether cancer treatments differ in infertile men compared to men who have undergone vasectomy and age‐matched controls. We analyzed subjects from the Truven Health MarketScan Claims database from 2001 to 2009. Infertile men were identified through diagnosis and treatment codes. Comparison groups included vasectomized men and an age‐matched cohort who were not infertile and had not undergone vasectomy. We considered cancer types previously associated with infertility that were diagnosed after the diagnosis of infertility. The treatment regimens were determined based on the presence of claims...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
AbstractAdult survivors of childhood cancers are more prone to developing poor reproductive and obstetrical outcomes than their siblings and the general population as a result of previous exposure to chemotherapy and radiation during childhood. Chemotherapy drugs exert cytotoxic effects systemically and therefore can damage the ovaries, leading to infertility, premature ovarian failure, and, to a lesser extent, spontaneous abortions. They have very limited or no deleterious effects on the uterus that can be recognized clinically. By contrast, radiation is detrimental to both the ovaries and the uterus, thereby causing a gr...
Source: The Oncologist - Category: Cancer & Oncology Authors: Tags: Review, Gynecologic Oncology Source Type: research
ConclusionsFP for oncology patients is a positive strategy. The women in this study felt that FP was a worthwhile process and that the security of having undergone FP brought them peace during oncological treatment and contributed to their quality of life.
Source: Journal of Assisted Reproduction and Genetics - Category: Reproduction Medicine Source Type: research
I could continue to obsess over cold facts, or I could choose to be present and enjoy all the beautiful moments that make life worth living.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Hodgkin's Lymphoma Infertility Drugs (Pharmaceuticals) Headaches Epilepsy Anxiety and Stress Chemotherapy Statistics Source Type: news
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