Top Ten Medical Research Issues and Trends to Watch in 2017

2016 will go down as a year that taught us to question our assumptions. The election of Donald Trump, an outcome almost no one predicted, left many with a sense of uncertainty about what 2017 will bring in the biomedical and health-care space. To bring clarity to these unsure times, FasterCures has compiled a list of issues critical to the future of medical innovation that we'll be tracking over the coming year. While some issues will be closely linked with the people and policies of the new presidential administration, we think all will be important to continuing the progress toward faster cures and treatments. 1. FDA: What is the roadmap going forward? 2017 could be an exceptionally important year at the Food and Drug Administration (FDA). We don't know who will lead the FDA as commissioner, and at least one senior leader has announced his retirement. We know that the dust-up over the agency's approval in September of Sarepta's Exondys 51 for Duchenne muscular dystrophy has led to a lot of discussion about how decisions will be made going forward. And we know the number of approvals in 2016 was lower than the record-breaking numbers of recent years, due to a declining number of New Drug Applications from industry, though some fingers will undoubtedly be pointed at the agency. The 21st Century Cures Act, passed in December, contains some "real but modest regulatory innovations" that are being portrayed by some (erroneously, we believe) as reducing FDA's standar...
Source: Science - The Huffington Post - Category: Science Source Type: news

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Publication date: Available online 21 March 2019Source: Journal of Molecular Graphics and ModellingAuthor(s): Pourseyed Aghaei Fatematossadat, Mahnaz Mohammadi, S. Ehsan RoozmehAbstractIn this paper, we study magnetic and structural properties of silver and gold-coated iron nanoparticle as novel drug delivery systems for the two commercially famous cancer treatment drugs, using the density functional theory (DFT) computations.Our calculations show that silver and gold-coated iron nanoparticle have magnetization and the magnetic moment of the Fe atom in the Fe@(Ag/Au)n core-shells saturated to a value of about 3 μB. Thus...
Source: Journal of Molecular Graphics and Modelling - Category: Molecular Biology Source Type: research
ConclusionOur study suggests a VDR-mediated metabolic cross-talk between gut and adipose tissue, which significantly contributes to systemic lipid homeostasis. These results have important implications for use of the intestinal VDR as a therapeutic target for obesity and associated disorders.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
Publication date: Available online 21 March 2019Source: Carbohydrate PolymersAuthor(s): Shuo Tang, Ting Wang, Caoxing Huang, Chenhuan Lai, Yimin Fan, Qiang YongAbstractA highly branched arabinogalactan isolated from Larix principis-rupprechtii and subjected to sulfation derivatization to promote their antitumor bioactivity. Several structural features of the sulfated arabinogalactans (S-LAG) were investigated: molecular weight, monosaccharide constitution, and chemical structures. Spectral analysis indicated that sulfate groups were successfully introduced on arabinogalactan. Sulfated products showed different degrees of s...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 21 March 2019Source: MitochondrionAuthor(s): Hamza El Hadi, Roberto Vettor, Marco RossatoAbstractCardiovascular disease is the leading cause of diabetes-related morbidity and mortality. It is widely accepted that heart failure risk is increased in diabetic patients even after adjusting for coronary artery disease and hypertension. Mitochondria are the center of fatty acid (FA) and glucose metabolism and thus are likely to be impacted by impaired metabolism associated with diabetes. Although the cause of this increased heart failure risk is multifactorial, increasing evidence points toward...
Source: Mitochondrion - Category: Biochemistry Source Type: research
ConclusionsO-GlcNAcylation significantly modified STRA6 and RALDH1, suppressed RBP4 binding activity, and disrupted retinol signals in the kidney of diabetes.General significanceThis study first indicates that STRA6-retinol signals were directly disrupted by O-GlcNAcylation in diabetic kidney.
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research
Publication date: Available online 21 March 2019Source: The Journal of Supercritical FluidsAuthor(s): Daniel Ribeiro Grijó, Danielle Lazarin Bidoia, Celso Vataru Nakamura, Ignacio Vieitez Osorio, Lúcio Cardozo-FilhoAbstractThe inhibitory effects of Cannabis flower extracts, obtained by supercritical carbon dioxide (scCO2) with and without modifier, on various human tumour cells and non-tumour cells were evaluated. Different techniques were used to optimize the polarity interaction between solute and solvent before extraction. An increase in the cannabinoid content of interest (CBD/THC) was evaluated by decarb...
Source: The Journal of Supercritical Fluids - Category: Chemistry Source Type: research
Publication date: Available online 22 March 2019Source: European Polymer JournalAuthor(s): Qian Zou, Fangli Hou, Hong Wang, Yonggui Liao, Qin Wang, Yajiang YangAbstractMultifunctional alginate microspheres encapsulated with in situ-formed bismuth sulfide nanoparticles (denoted as Bi2S3@BCA) were developed in this work. In comparison with conventional hybrid polymer microspheres usually involved in complicate preparation process, Bi2S3@BCA microspheres can be easily one-step prepared using a droplet-based microfluidic technique with alginate as a soft template and microspheric matrix. As-prepared Bi2S3@BCA microspheres has ...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 March 2019Source: European Polymer JournalAuthor(s): Aliyeh Ghamkhari, Farideh Mahmoodzadeh, Marjan Ghorbani, Hamed HamishehkarAbstractGold nanoparticles have been used for centuries in medicine for clinical procedures. In this context, gold nanorods are considered as very promising in cancer therapy. For this purpose, gold nanorods (GNRs) coated by stimuli-responsive thiol-end capped ABC triblock copolymer [poly (metacrylic acid)-block-poly (N-isopropylacrylamide)-block-poly (N,N-dimethylaminoethyl methacrylate)-SH; P(MAAc-b-NiPAAM-b-DMAEMA)-SH] for intracellular delivery of doxorubic...
Source: European Polymer Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 March 2019Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Yongchao Zhang, Zhenfen Tian, Xiaotong Zhao, Na Li, Vasil M. Garamus, Peihao Yin, Aihua ZouAbstractBufalin, a traditional oriental medicine, has been incorporated into liposomes for better targeted drug delivery. Bufalin-loaded liposome (L-BF), bufalin-loaded PEGylated liposome (L-PEG-BF) and bufalin-loaded RGD targeted PEGylated liposome (L-RGD-PEG-BF) were successfully developed with homogeneous particle size and sufficient physical stability in 30 days. The entrapment efficiency (EE) and dru...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
In this study, we reported a dual HDAC and DNMT inhibitor 208 and found it induced G1 cell cycle arrest and apoptosis in U937 cells. Proteome and bioinformatic analyses revealed that the combined inhibition of DNMT1 and HDAC by 208 affected the expression of a series of proteins involved in many biological processes. We observed that several proteins associated with G1 cell cycle arrest and apoptosis were down regulated after 208 treatment, including p85α, MEK, and CDK4, suggesting that 208 induces cell cycle arrest and apoptosis through the p85α/MEK-mediated pathway in U937 cells. Moreover, biological function...
Source: Chinese Chemical Letters - Category: Chemistry Source Type: research
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