In Utero Exposure to BenzoaPyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice

Conclusion: In utero exposure to environmental mutagens contributes to somatic and germline mosaicism, permanently affecting both the genetic health of the F1 and the population gene pool. Citation: Meier MJ, O’Brien JM, Beal MA, Allan B, Yauk CL, Marchetti F. 2017. In utero exposure to benzo[a]pyrene increases mutation burden in the soma and sperm of adult mice. Environ Health Perspect 125:82–88; http://dx.doi.org/10.1289/EHP211 *These authors contributed equally to this work. Address correspondence to F. Marchetti, Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario, K1A 0K9, Canada. Telephone: 1-613-9573137. E-mail: francesco.marchetti@canada.ca Currrent address for J.M.O.: Ecotoxicology and Wildlife Health Division, Environment Canada, Ottawa, ON, Canada. We acknowledge technical assistance from M. Rosales, J. Gingerich, and L. Soper. We are thankful for comments received from D. Desaulniers and M. Wade. This work was supported by Health Canada intramural funding. Stipend support to M.J.M., M.A.B., and J.M.O. was provided by the Natural Sciences and Engineering Research Council of Canada and by the Canadian Institutes of Health Research (CIHR) Training Program in Reproduction, Early Development, and the Impact on Health. The authors declare they have no actual or potential competing financial interests. Received: 23 March 2016 Revised: 13 June 2016 Accepted: 23 June 2016 Published: 22 July 2016 ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Research Articles January 2017 Source Type: research

Related Links:

Publication date: April 2020Source: Phytochemistry Letters, Volume 36Author(s): Fahd M. Abdelkarem, Ezz-Eldin K. Desoky, Alaa M. Nafady, Ahmed E. Allam, Aldoushy Mahdy, Maki Nagata, Tomofumi Miyamoto, Kuniyoshi ShimizuAbstractFurther chemical study of the crude extract of the soft coral Heteroxenia fuscescens (Fam., Xeniidea), led to isolation of two new sterols, Heterofuscesterols A (1) and B (2), a sterol isolated for the first time from natural sources, 3β,5α,6β-trihydroxyandrosta-17-one (3), along with one new hydroperoxy sesquiterpene, Heterofusceterpene A (4), and one known ceramide (5). Their structu...
Source: Phytochemistry Letters - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Meitong Ou, Chao Pan, Yongkang Yu, Xuan Wang, Yun Zhou, Hanjie Zhang, Qinzhen Cheng, Meiying Wu, Xiaoyuan Ji, Lin MeiAbstractExcessive reactive oxygen species (ROS), as effective cancer therapeutic agents, can promote tumor apoptosis. However, the clinical applications of ROS-mediated cancer therapies still have many limitations, such as self-defects of traditional photosensitizer, adverse tumor microenvironment (TME), and insufficient ROS production. Here, two-dimensional and highly oxidized ilmenite nanosheets (HOIL NSs, for...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 21 February 2020Source: Chemical Engineering JournalAuthor(s): Yang Zhang, Yanjun Xu, Di Sun, Zheying Meng, Weiwei Ying, Wei Gao, Rui Hou, Yuanyi Zheng, Xiaojun Cai, Bing Hu, Xianfang LinAbstractAs a promising treatment modality with spatial and temporal control, alternating magnetic field (AMF) triggered magnetic hyperthermal therapy (MHT) shows broad and promising applications to overcome the drawbacks of traditional focal therapies in combating cancer. However, the MHT efficacy is still not satisfactory with the presence of heat shock proteins (HSPs). In addition, sustained tumor hypox...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
In this study, the anti-aging... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Photochem. Photobiol. Sci. latest articles - Category: Chemistry Authors: Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/D0CC00416B, CommunicationXinwei Tian, Zhao Li, Ning Ding, Jiahang Zhang We have developed a novel near-infrared ratiometric fluorescent theranostic nanoprobe. Reaction with glutathione, it would release a near-infrared fluorophore and chemotherapy drug. Notably, this nanoprobe can selectively kill cancer HeLa,... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
We report the first two patients, who underwent in vitro maturation protocol in order to avoid the exacerbation risk due to controlled ovarian stimulation at a large tertiary university hospital. Both patients were referred to our infertility clinic with the concern of multiple sclerosis exacerbation after or during controlled ovarian stimulation treatment. The patients underwent in vitro maturation protocol in order to avoid ovarian stimulating agents. Both patients gave birth to healthy babies at term. They did not suffer any multiple sclerosis relapses during their treatment and during pregnancy. Controlled ovarian stim...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
This study demonstrated that there was a higher abundance of sRNA in the pig farm WWTPs and 52 sRNAs were detected. The sRNAs were mainly present in Proteobacteria and Firmicutes, including the potential human pathogenic bacteria (HPB) (Escherichia, Shigella, Bordetella and Morganella), crop pathogen (Pectobacterium) and denitrifying bacteria (Zobellella). And the sRNAs were involved in the bacterial functional activities such as translation, transcription, drug resistance, membrane transport and amino acid metabolism. In addition, most sRNAs had a higher abundance in anoxic tanks which contained a higher abundance of the ...
Source: Journal of Environmental Sciences - Category: Environmental Health Source Type: research
In this study, an analysis of the potential mechanism underlying photocatalytic disinfection was performed based on integrated metabolic networks and transcriptional data. Two sets of RNA-seq data (wild type and a photocatalysis-resistant mutant mediated by titanium dioxide (TiO2)) were processed to constrain the genome scale metabolic models (GSMM) of E. coli. By analyzing the metabolic network, the differential metabolic flux of every reaction was computed in constrained GSMM, and several significantly differential metabolic fluxes in reactions were extracted and analyzed. Most of these reactions were involved in the tra...
Source: Journal of Environmental Sciences - Category: Environmental Health Source Type: research
Conclusions: This municipality needs to reach mothers with lower socioeconomic status, restructure the local health services, and enhance their operationalization to improve the quality of prenatal care.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
ABSTRACT: Objectives: To estimate the magnitude of gender differences in disability among adults aged 60 and older and to evaluate whether they can be associated with social gender inequality and socioeconomic contextual factors at the level of Brazilian federative units. Methods: This is a multilevel study that used data from 23,575 older adults of 27 federative units who participated in the 2013 Brazilian Health Survey. The activity limitation index was developed from the item response theory, using activities of daily living and instrumental activities of daily living variables. The association of individual and context...
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
More News: Alzheimer's | Autism | Biology | Brain | Brain Cancers | Cancer | Cancer & Oncology | Carisoprodol | Chemistry | Computers | Databases & Libraries | Disability | Environmental Health | Epilepsy | Gastroenteritis | Gastroenterology | Gastroschisis Repair | Genetics | Germ Cell Tumors | Hodgkin's Disease | Infertility | Legislation | Liver | Medical Ethics | Molecular Biology | Neurology | Neuroscience | Nutrition | Occupational Health | Oral Cancer | Ovarian Cancer | Ovaries | Perinatology & Neonatology | Pregnancy | Reproduction Medicine | Science | Soma | Statistics | Stem Cell Therapy | Stem Cells | Study | Toxicology | Training | Universities & Medical Training | Urology & Nephrology