ANGPTL3 facilitates β-adrenergic-dependent lipolysis in adipocytes: Evidence from in vitro studies

Background: ANGPTL3 deficiency is associated with decreased plasma concentration of free fatty acids (FFA). The molecular mechanism underlying this effects remains unclear. The inter-prandial lipolysis of TG contained in adipose tissue is considered to be the major source of FFA. Therefore, we hypothesized that ANGPTL3 may play a role in modulating the β-adrenergic-dependent lipolysis in adipocytes.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research