Role of Lipoprotein-associated phospholipase A2 in ischemic stroke patients treated with tPA thrombolysis: The magic study

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2), a member of phospholipase A2 proteins family that plays a key role in the metabolism of pro-inflammatory phospholipids, as oxidized low-density lipoproteins, and in the generation of pro-atherogenic metabolites, including lysophosphatidylcholine and oxidized free fatty acids which may affect vessel walls. Several studies have demonstrated that LpPlA2 is an independent risk marker for ischemic stroke. However, scarce data exist in IS patients treated with tPA.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research