Lipoprotein-associated phospholipase A2 circulating levels in the general population of the Montignoso Study

Background: Lipoprotein-associated phospholipase A2 (Lp-PLA2), a member of phospholipase A2 proteins family that plays a key role in the metabolism of pro-inflammatory phospholipids, as oxidized low-density lipoproteins, and in the generation of pro-atherogenic metabolites, including glysophosphatidylcholine and oxidized free fatty acids which may affect vessel walls. Several studies have demonstrated that LpPlA2 is an independent risk marker for cardiovascular disease. However, few data about the relationship between LpPlA2, lipoprotein(a) [Lp(a)] and calcium score exist in the general population.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - Category: Nutrition Authors: Source Type: research