Exosomes Promote Ovarian Cancer Cell Invasion through Transfer of CD44 to Peritoneal Mesothelial Cells

This study indicates that ovarian cancer–derived exosomes transfer CD44 to HPMCs, facilitating cancer invasion. Implications: Mechanistic insight from the current study suggests that therapeutic targeting of exosomes may be beneficial in treating ovarian cancer. Mol Cancer Res; 15(1); 78–92. ©2016 AACR.

http://mcr.aacrjournals.org/cgi/content/short/15/1/78?rss=1

Source: Molecular Cancer Research - January 2, 2017 Category: Cancer & Oncology Authors: Nakamura, K., Sawada, K., Kinose, Y., Yoshimura, A., Toda, A., Nakatsuka, E., Hashimoto, K., Mabuchi, S., Morishige, K.-i., Kurachi, H., Lengyel, E., Kimura, T. Tags: Signal Transduction Source Type: research