Src Family Kinases Are Regulated in Multiple Myeloma Cells by Phosphatase of Regenerating Liver-3

In conclusion, PRL-3 protected MM cells against apoptosis by dysregulating both the total levels and the activation levels of specific SFK members that are important for IL6 signal transduction in MM cells. Eventually, this led to increased levels of Mcl-1. Implications: This study suggests PRL-3 and SFKs are key mediators of the IL6-driven signaling events and points to both PRL-3 and SFK members as potential targets for treatment of MM. Mol Cancer Res; 15(1); 69–77. ©2016 AACR.

http://mcr.aacrjournals.org/cgi/content/short/15/1/69?rss=1

Source: Molecular Cancer Research - January 2, 2017 Category: Cancer & Oncology Authors: Abdollahi, P., Vandsemb, E. N., Hjort, M. A., Misund, K., Holien, T., Sponaas, A.-M., Ro, T. B., Slordahl, T. S., Borset, M. Tags: Signal Transduction Source Type: research