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By the Editors NEJM Group offers so many valuable resources for clinicians. Here's what we chose for you today:NEJM Clinical Practice Center: Review article: Myasthenia …
Source: Physician's First Watch current issue - Category: Primary Care Source Type: news

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Authors: Scoppetta C, Casciato S, Di Gennaro G PMID: 32767317 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: September 2020Source: Journal of Clinical Neuroscience, Volume 79Author(s): Xin Fan, Chunye Xing, Li Yang, Jing Wang, Lisha Feng
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Timely and accurate diagnosis of myasthenia gravis, particularly in patients with fluctuating, isolated ocular involvement, remains challenging. Serological antibody testing and repetitive nerve stimulation of peripheral muscles usually have low sensitivity in these patients. Edrophonium testing may cause adverse events, single-fiber electromyography (SFEMG) is time-consuming and both tests are often unavailable outside specialized institutions. Repetitive ocular vestibular evoked myogenic potential (roVEMP) stimulation has recently been introduced to facilitate the diagnosis of myasthenia gravis. Similar to repetitive ner...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Myasthenia Gravis (MG) is an autoimmune neuromuscular disease characterized by skeletal muscle weakness and fatigability. Disease severity and pattern of muscle weakness varies widely between patients, as does the risk of myasthenic crisis, which is a severe and potentially fatal condition characterized by respiratory insufficiency requiring intensive care and mechanical ventilation. There is growing knowledge on comorbidities in patients with MG [1], e.g. increased risk of other autoimmune conditions, especially in patients with early-onset disease (EOMG) [2,3], increased risk of cardiovascular disorders in patients with ...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
PMID: 32776781 [PubMed - as supplied by publisher]
Source: Annals of Internal Medicine - Category: Internal Medicine Authors: Tags: Ann Intern Med Source Type: research
AbstractPurpose of ReviewImmune checkpoint inhibition for treatment of metastatic cancers is recognized to cause diverse immune-mediated neurological syndromes. This review will discuss current knowledge about the frequency and varied presentation of these syndromes affecting the peripheral nervous system as well as detail important diagnostic and management considerations.Recent FindingsImmune-related adverse events affect the peripheral nervous system more often than the central nervous system, and rates are likely underestimated. Most data regarding neurological immune –related adverse events are retrospective, an...
Source: Current Treatment Options in Neurology - Category: Neurology Source Type: research
Publication date: Available online 30 July 2020Source: Journal of Pediatric Surgery Case ReportsAuthor(s): F. Grasso, L. De Leonibus, M. Bertozzi, M. Sica, R. Angotti, L. Luzzi, F. Molinaro, M. Messina, P. Paladini
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Background: Four main clinical phenotypes have been traditionally described in patients mutated in SCN4A, including sodium-channel myotonia (SCM), paramyotonia congenita (PMC), Hypokaliemic type II (HypoPP2), and Hyperkaliemic/Normokaliemic periodic paralysis (HyperPP/NormoPP); in addition, rare phenotypes associated with mutations in SCN4A are congenital myasthenic syndrome and congenital myopathy. However, only scarce data have been reported in literature on large patient cohorts including phenotypes characterized by myotonia and episodes of paralysis.Methods: We retrospectively investigated clinical and molecular featur...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
The benefits of physical exercise for healthy individuals are well-established, particularly in relation to reducing the risks of chronic lifestyle related diseases. Furthermore, physical exercise has been seen to provide beneficial effects in many chronic diseases such as multiple sclerosis, rheumatoid arthritis, and chronic obstructive pulmonary disease and is therefore recommended as part of the treatment regimen. Myasthenia Gravis (MG) is a chronic autoimmune disease that causes neuromuscular transmission failure resulting in abnormal fatigable skeletal muscle weakness. In spite of this fluctuating skeletal muscle weak...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
We present a 61 ‐year‐old man with severe myasthenia gravis, nonresponsive to conventional therapy. The patient was treated with individualized homeopathy, demonstrating significant improvement on his clinical status and no disease symptoms. AbstractWe present a 61 ‐year‐old man with severe myasthenia gravis, nonresponsive to conventional therapy. The patient was treated with individualized homeopathy, demonstrating significant improvement on his clinical status and no disease symptoms.
Source: Clinical Case Reports - Category: General Medicine Authors: Tags: CASE REPORT Source Type: research
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