Three new isobenzofurans from Lavandula angustifolia and their bioactivities

Publication date: March 2017 Source:Phytochemistry Letters, Volume 19 Author(s): Min Zhou, Huan-Huan Xing, Hang-Ying Ma, Lin Zhou, Yan Yang, Gan-Peng Li, Wei-Yao Hu, Qiang Liu, Xue-Mei Li, Qiu-Fen Hu Three new isobenzofurans, lavandulactones A–C (1–3), together with three known ones (4–6), were isolated from the whole herb of Lavandula angustifolia. Their structures were established on the basis of detailed spectroscopic analysis (1D- and 2D-NMR, HRESIMS, UV, and IR) and comparison with data reported in the literature. New isolates were evaluated for their anti-tobacco mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds 1–3 showed high anti-TMV activity with inhibition rate of 31.8, 29.6 and 33.4%, respectively. These rates are higher than that of positive control. Compounds 1–3 also showed weak inhibitory activities against some tested human tumor cell lines with IC50 values ranging from 1.5 to 5.7μM. Graphical abstract

Source: Phytochemistry Letters - January 2, 2017 Category: Chemistry Source Type: research