Solving the Mystery Flu That Killed 50 Million People

MoreCalifornia Bill Banning ‘Affluenza’ Defense Is Nixed7 Ebola Patients in Guinea Fight Off the Disease4 Diseases Making a Comeback Thanks to Anti-VaxxersYears ago the environmental historian Alfred Crosby was at Washington State University, where he was teaching at the time, when on a whim he decided to pick up an old almanac from 1917. (This is apparently the kind of thing historians like to do in their spare time.) He looked up the U.S. life expectancy in that year—it was about 51 years. He turned to the 1919 almanac, and found about the same figure. Then Crosby picked up the almanac from 1918. The U.S. life expectancy in 1918 had fallen to 39 years. “What the hell happened?” Crosby told the New York Times writer Gina Kolata in her book Flu: The Story of the Great Influenza Pandemic of 1918. “ The life expectancy had dropped to what it had been fifty years before.” MoreMumps Outbreak Reported at University of IllinoisAlmost Half of Homeless Men Had a Previous Brain InjuryMen Charged With Toppling Ancient Rock Formation Avoid Jail Time Huffington PostHere's An Updated Tally Of All The People Who Have Ever Died From A Marijuana Overdose Huffington PostTony Awards 2014: Neil Patrick Harris, Bryan Cranston, Chris O'Dowd Score Nods PeopleWhat happened was the 1918 influenza pandemic. A virus that usually does little more than make people feel awful for a few days killed an estimated 50 million people worldwide, if not far more, with 65...
Source: TIME: Top Science and Health Stories - Category: Science Authors: Tags: Uncategorized 1918 pandemic avian flu bird flu death rates H1N1 H5N1 H7N9 health immune system influenza Spanish flu Source Type: news

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Publication date: December 2018Source: American Journal of Preventive Medicine, Volume 55, Issue 6Author(s):
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
In this study, we generated VLPs containing hemagglutinin (HA), neuraminidase (NA) or M1 proteins derived from the A/California/04/09. Mice were immunized intramuscularly with HA-M1, NA-M1 or M1 VLPs and protective immunity was evaluated by assessing lung virus loads against low (5LD50) or high (100LD50) lethal dose of homologous virus challenges. High levels of virus-specific serum IgG antibody responses were induced in mice after HA-M1 VLPs immunization, whereas low or no IgG antibody responses were detected from immunization with NA-M1 VLPs or M1 VLPs, independently. Mice that were immunized with HA-M1 VLPs showed below...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
ConclusionPresence of the fosA3 gene on the same common plasmid as blaCTX-M-8 will have to be monitored. This draft genome provides data that will help in tracing the dissemination of this gene and the evolution of its plasmidic support.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsThe current study indicates that a history of OSAS/CSAS, myocardial infarction and BMI > 30 might be related to ICU admission in influenza patients. Second, ICU patients develop more pulmonary co-infections. Last, (pre-existent) renal failure and diabetes mellitus are more often observed in non-survivors.
Source: Journal of Critical Care - Category: Gastroenterology Source Type: research
LOWELL (CBS) – A second case of measles has been diagnosed in Lowell and there may have been exposure to that person in Chelmsford and Tewksbury, state health officials confirmed Saturday. The latest case was discovered at the Lowell Community Health Center on Thursday, November 15, seven days after a two-year-old boy came down with the measles there. No information was released about the second person. “The individual was present in a number of locations that could have resulted in exposures to other people,” the Massachusetts Department of Public Health said in a statement. “There are no known lin...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Boston News Health Syndicated Local Lowell Measles Source Type: news
Publication date: December 2018Source: Trends in Pharmacological Sciences, Volume 39, Issue 12Author(s): Sade E. Johns, Mary Bowman, F. Gerard MoellerThe United States is currently in the midst of an opioid epidemic. Barriers to treatment in the emergency department can lead to missed opportunities for helping prevent overdose and relapse in individuals with opioid use disorder. The administration of buprenorphine in the emergency department can potentially lead to better treatment outcomes for these individuals.
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Publication date: December 2018Source: Trends in Pharmacological Sciences, Volume 39, Issue 12Author(s): Michael H. Baumann, Theresa A. Kopajtic, Bertha K. MadrasThe United States is experiencing an epidemic of opioid overdose deaths. Many of the recent fatalities are associated with illicitly manufactured fentanyl, which is being added to heroin and counterfeit pain pills. The crisis is further exacerbated by the emergence of an increasing number of novel synthetic opioids (NSOs), including various fentanyl analogs and non-fentanyl compounds that display potent agonist actions at the μ-opioid receptor. Importantly, mos...
Source: Trends in Pharmacological Sciences - Category: Drugs & Pharmacology Source Type: research
Authors: Han Y, Mesplède T Abstract INTRODUCTION: The Zika virus (ZIKV) infection results in severe neurological complications and has emerged as a threat to public health worldwide. No drugs or vaccines are available for use in the clinic and the need for novel and effective therapeutic agents is urgent. Areas covered: This review describes the latest progress of antiviral development for the treatment of ZIKV infection; it primarily focuses on the literature describing twenty potential anti-ZIKV drugs/agents currently being tested in vivo or in clinical trials. The paper also discusses the need for novel Z...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research
Publication date: Available online 16 November 2018Source: Materials TodayAuthor(s): Rostyslav Bilyy, Solomiya Paryzhak, Kostiantyn Turcheniuk, Tetiana Dumych, Alexandre Barras, Rabah Boukherroub, Fujia Wang, Gleb Yushin, Sabine SzuneritsAbstractImproving efficiency of an adjuvant, material that enhances the body’s immune response to an antigen, has become vital for the development of safer, cheaper, and more effective next-generation vaccines. Commercial vaccines typically use aluminum salt-based adjuvant particles, most commonly aluminum oxyhydroxide (AlOOH) and aluminum hydroxide (Al(OH)3) based, often referred to...
Source: Materials Today - Category: Materials Science Source Type: research
Publication date: December 2018Source: Seminars in Cell &Developmental Biology, Volume 84Author(s): Christophe Macri, Ee Shan Pang, Timothy Patton, Meredith O’KeeffeAbstractDendritic cells (DC) are professional antigen presenting cells comprising a variety of subsets, as either resident or migrating cells, in lymphoid and non-lymphoid organs.In the steady state DC continually process and present antigens on MHCI and MHCII, processes that are highly upregulated upon activation. By expressing differential sets of pattern recognition receptors different DC subsets are able to respond to a range of pathogenic and dan...
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
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