The relationship between maternal self-efficacy, compliance and outcome in a trial of vitamin D supplementation in pregnancy

AbstractSummaryIn a randomised controlled trial of vitamin D during pregnancy, we demonstrated that women with lower self-efficacy were more likely to experience practical problems with taking the trial medication and that this was associated with lower compliance and achieved 25(OH)-vitamin D concentrations.IntroductionThe relationship between self-efficacy (the belief that one can carry out a behaviour), compliance with study protocol and outcome was explored within a randomised, double-blind, placebo-controlled trial of vitamin D supplementation in pregnancy.MethodsIn the Maternal Vitamin D Osteoporosis Study (MAVIDOS) trial, women with circulating plasma 25(OH)-vitamin D of 25 –100 nmol/l in early pregnancy were randomised to either 1000 IU cholecalciferol/day or matched placebo from 14 weeks until delivery. Circulating 25(OH)-vitamin D concentrations were assessed at 14 and 34 weeks’ gestation. A sequential sub-sample completed Schwarzer’s General Self-Efficacy Scale at 14 and 34 weeks and the Problematic Experiences of Therapy Scale at 34 weeks. Women were interviewed about their experiences of the trial and interview transcripts analysed thematically.ResultsIn 203 women, those with higher self-efficacy were less likely to experience practical problems taking the study medication (odds ratio (OR) 0.81 (95  % confidence interval (CI) 0.69–0.95),p = 0.01). Over half reported practical problems associ...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research

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Often we don’t really consider gender dynamics in treatment or medication. A lot of medications are only tested on men because of the risk of pregnancy, etc. This means there are whole drugs that have made it to market that may not have ever been tested with women. Schizophrenia affects women in many different ways than men. In this episode schizophrenic Rachel Star Withers and cohost Gabe Howard discuss differences in age, symptoms, treatments, lifestyle, parenthood in the genders as they experience schizophrenia. Dr. Hayden Finch joins to explain the medical side.  Highlights in “Schizophrenia in Women...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Mental Health and Wellness Women's Issues Gender Differences Mental Disorder Mental Illness Psychiatry Psychology Psychotherapy Women's Health women's mental health Source Type: blogs
Publication date: Available online 22 January 2020Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Stephanie A. Atkinson, James C. FleetAbstractIn 2016, the Multiple Sclerosis (MS) Society of Canada convened a panel of expert scientists, clinicians and patient advocate to review the evidence for an association between vitamin D status and MS prevention and/or disease modification. The goal was to develop clear and accurate recommendations on optimal vitamin D intake and status for people affected by MS for use in clinical practice and public health policy. The final consensus report was based on ...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
Menopause before age 45 increases the risk of early death, cognitive decline, osteoporosis and cardiovascular disease.
Source: National Institutes of Health (NIH) News Releases - Category: American Health Source Type: news
Antiphospholipid antibody syndrome (APS) is an autoimmune disease characterized by thromboembolic events or pregnancy-related complications caused by antiphospholipid antibodies. The following case reports a patient diagnosed with APS, osteoporosis, and atherosclerosis. The medication for treatment and control of the diseases were warfarin, low-molecular-weight heparin, aspirin, and alendronate. Clinical and radiographic examination revealed an intraoral fistula, with spontaneous purulent drainage in a 2-month previous tooth extraction area and signs of bone sequestrum both compatible with medication-related osteonecrosis of the jaw (MRONJ).
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - Category: ENT & OMF Authors: Source Type: research
AbstractPurpose of reviewThis review summarizes recently published data on the effects of pregnancy and lactation on bone structure, mechanical properties, and mechano-responsiveness in an effort to elucidate how the balance between the structural and metabolic functions of the skeleton is achieved during these physiological processes.Recent findingsWhile pregnancy and lactation induce significant changes in bone density and structure to provide calcium for fetal/infant growth, the maternal physiology also comprises several innate compensatory mechanisms that allow for the maintenance of skeletal mechanical integrity. Both...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
ConclusionPLO has a significant impact on pain, mental state, quality of life, and capacity to work. However, the long-term prognosis is promising. The severe mental distress is presumably related to several contributing factors in life such as physical integrity and independence, family life, employment, and financial security.Key Points• PLO has a strong impact on quality of life and can lead to severe mental distress.• At onset of symptoms, patients with PLO are in very poor mental and physical condition; however, the long-term outcome after inpatient rehabilitation seems to be good.• Most patients do not...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
Spécificités du traitement médicamenteux antihypertenseur chez la femme. Presse Med. 2019 Nov 14;: Authors: Amar J, Angoulvant T, Boivin JM, Amar L, Lantelme P, Blacher J, Plu-Bureau G, Vehier CM Abstract The impact of antihypertensive drugs on blood pressure does not differ according to the sex. There are women-specific conditions or medical conditions encountered more frequently among womens that guide the selection of therapy such as a desire to become pregnant, a pregnancy, a polycystic ovarian syndrome, breast cancer, osteoporosis or migraine. PMID: 31735525 [PubMed - as...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
Conclusion: A negative correlation was found between estrogen and bone density. A significant difference in salivary calcium was noted in the study groups, highlighting the role of salivary calcium in the detection of early bone changes in postmenopausal women.
Source: Journal of Oral and Maxillofacial Pathology - Category: ENT & OMF Authors: Source Type: research
Source: Gynecological Endocrinology - Category: Endocrinology Authors: Source Type: research
AbstractBackgroundLower semen quality is associated with increased mortality and morbidity, which may include osteoporosis.ObjectiveTo assess whether infertile men have a lower bone mineral density (BMD) compared with fertile men at the time of fertility workup.MethodsA total of 146 men from infertile couples with unexplained impaired semen quality, characterized by sperm concentration  
Source: Andrology - Category: Urology & Nephrology Authors: Tags: Original Article Source Type: research
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