Cardiac energetics, oxygenation, and perfusion during increased workload in patients with type 2 diabetes mellitus

Conclusion
The pre-existing energetic deficit in diabetic cardiomyopathy is exacerbated by exercise; stress PCr/ATP correlates with impaired perfusion and oxygenation. Our findings suggest that, in diabetes, coronary microvascular dysfunction exacerbates derangement of cardiac energetics under conditions of increased workload.

Source: European Heart Journal - December 29, 2016 Category: Cardiology Authors: Levelt, E., Rodgers, C. T., Clarke, W. T., Mahmod, M., Ariga, R., Francis, J. M., Liu, A., Wijesurendra, R. S., Dass, S., Sabharwal, N., Robson, M. D., Holloway, C. J., Rider, O. J., Clarke, K., Karamitsos, T. D., Neubauer, S. Tags: Obesity and metabolic syndrome Source Type: research