Connexin43 and myocardial ischemia-reperfusion injury.

Connexin43 and myocardial ischemia-reperfusion injury. Cardiovasc Hematol Disord Drug Targets. 2016 Dec 27; Authors: Zu L, Wen N, Liu C, Zhao M, Zheng L Abstract The treatment and prevention of ischemic cardiomyopathy is one of the most concerned research points in cardiovascular field recently. Gap junction is the basic structure of cardiac electrophysiology, connexin is the basic unit of gap junctions, Connexin43(Cx43) is the most abundant member of Cx family in heart ,the normal expression of Cx43 is crucial for heart development,electrically coupled cardiomyocytes activities and the regulation of myocardial function. The connection between Cx43 and myocardial ischemia/reperfusion or reperfusion injury has become the current research focus. PMID: 28029075 [PubMed - as supplied by publisher]
Source: Cardiovascular and Hematological Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Cardiovasc Hematol Disord Drug Targets Source Type: research

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LEFT VENTRICULAR LEAD PLACEMENT FOR PACING AND SENSING IN A PATIENT WITH ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY UNDERGOING ICD IMPLANTATION. Acta Clin Croat. 2019 Jun;58(2):391-393 Authors: Taleski J, Manola Š, Radeljić V, Bulj N, Delić Brkljačić D, Pavlović N Abstract We present a case of a 64-year-old female patient scheduled for implantable cardioverter defibrillator (ICD) implantation due to arrhythmogenic right ventricular cardiomyopathy (ARVC). Dual coil, active fixation ICD lead was introduced through the axillary vein. More than 20 positions were changed in the right ventri...
Source: Acta Clinica Croatica - Category: General Medicine Tags: Acta Clin Croat Source Type: research
"Incompatible Housemates": Hypertrophic Obstructive Cardiomyopathy and Takotsubo Syndrome. Intern Med. 2019 Dec 06;: Authors: Sato Y, Matsumoto K, Sakai J, Nakamura T, Tanaka H, Hirata K Abstract This case report concerns an 81-year-old woman with previously well-controlled hypertrophic obstructive cardiomyopathy (HOCM). She was referred to our hospital because of the acute onset of takotsubo syndrome. Echocardiography revealed basal hyperkinesis due to takotsubo syndrome superimposed on septal hypertrophy, which resulted in the reappearance of prominent left ventricular outflow tract obstruc...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
We describe a family ascertained through 3 newborn screening (NBS) positive infants found to be unaffected themselves but in whom the mothers (sisters) were affected. There were also two affected children born to an affected male and his heterozygous wife who were false negatives on NBS but had increased fractional excretion of free carnitine in the urine. Analysis on a Next Generation Sequencing panel specifically designed to fully cover newborn screening disease targets showed a homozygous change in the five probands (SLC22A5; NM_003060:c.-149G > A; p.?). The mutation segregates with the CUD within the family. It ...
Source: Molecular Genetics and Metabolism - Category: Genetics & Stem Cells Source Type: research
Recent results of a collaborative study between Eko and the Mayo Clinic demonstrating the use of Eko’s DUO digital stethoscope as a heart failure screening tool suggest that the device could help identify asymptomatic patients with low ejection fraction during routine physical examinations. “The low ejection fraction algorithm was used with a very specific protocol of four touchpoints—three on the chest and one on the fingers,” said Steve Pham, MD, vice president of clinical and research affairs at Eko, in an interview with MD+DI. â&#...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Source Type: news
Sangeeta Khanna, Krishna Prasad, Vipin J Sharma, Nitul M BewalIndian Journal of Anaesthesia 2019 63(12):1041-1042
Source: Indian Journal of Anaesthesia - Category: Anesthesiology Authors: Source Type: research
Abstract The close connection and interaction between the cardiac and the liver functions are well-known, as cirrhotic cardiomyopathy is an important clinical entity which best describes the mutual pathogenical influence between these two organs. Due to the fact that cardiac dysfunction in patients with chronic hepatic disorders is oligosymptomatic or even asymptomatic, an early diagnosis represents a challenge for every physician. Syndecan-1-a transmembrane proteoglycan that exerts its functions mainly via its heparane sulfate chains-is a very promising biomarker, correlated not only with the degree of cardiac fi...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
Conditions:   Cardiomyopathy, Dilated;   Heart Failure;   Autoantibodies Intervention:   Drug: BC 007 Sponsor:   Berlin Cures GmbH Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Arrhythmogenic cardiomyopathy (ACM) is a familial heart disease, associated with ventricular arrhythmias, fibrofatty replacement of the myocardial mass and an increased risk of sudden cardiac death (SCD). Malignant ventricular arrhythmias and SCD largely occur in the pre-clinical phase of the disease, before overt structural changes occur. To prevent or interfere with ACM disease progression, more insight in mechanisms related to electrical instability are needed. Currently, numerous studies are focused on the link between cardiac arrhythmias and metabolic disease. In line with that, a potential role of mitochondrial dysfu...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Succinylation is a post-translational modification of protein lysine residues with succinyl groups derived from succinyl CoA. Succinylation is considered a significant post-translational modification with the potential to impact protein function which is highly conserved across numerous species. The role of succinylation in the heart, especially in heart failure and myofibril mechanics, remains largely unexplored. Mechanical parameters were measured in myofibrils isolated from failing hearts of ischemic cardiomyopathy patients and non-failing donor controls.
Source: Journal of Molecular and Cellular Cardiology - Category: Cytology Authors: Source Type: research
AbstractPurpose of reviewFunctional mitral regurgitation (MR) in setting of cardiomyopathy causes significant morbidity and worsened survival. Surgical therapies have failed to demonstrate significant overall benefit for functional MR. More recently, major trials utilizing transcatheter therapies for functional MR have been completed and offer new avenues for intervention. This review evaluates and compares 2 major recent trials designed to test the benefit of edge-to-edge repair using the MitraClip system for severe functional MR.Recent findingsThe Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy f...
Source: Current Treatment Options in Cardiovascular Medicine - Category: Cardiology Source Type: research
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