Drug discovery approach predicts health impact of endocrine-disrupting chemicals

 Breast cancer researchers from the Florida campus of The Scripps Research Institute (TSRI) have developed a novel approach for identifying how chemicals in the environment—called environmental estrogens—can produce infertility, abnormal reproductive development, including “precocious puberty ,” and promote breast cancer.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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Gui-Jiang Wei1,2, Ming-Qing Yuan1, Li-He Jiang1, Yu-Lan Lu3, Chun-Hong Liu3, Hong-Cheng Luo3, Hua-Tuo Huang3, Zong-Quan Qi1* and Ye-Sheng Wei1,2* 1Department of Cell Biology, Medical College of Guangxi University, Nanning, China 2Department of Medical Laboratory, Affiliated Hospital of Guilin Medical University, Guilin, China 3Department of Medical Laboratory, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, China miRNAs are small non-coding RNAs modulating gene expression, and variants in miRNA genes are involved in the pathogenesis of ischemic stroke (IS). However, the effect of mi...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Conclusion The periconceptional environment and lifestyle factors modify sperm epigenome. This alteration might be maintained in the zygote and throughout development, thereby leading to the inheritance of newly acquired pathologies. The role of sperm miRNA, not only as innovative markers of fertility issues but also as vectors involved in the inheritance of paternal diseases, appears to be crucial. Overweight and obesity seem to alter sperm miRNA profile, thereby leading to transmission of different miRNA profiles in zygote, with consequences on embryo development. In long term, metabolic disorders have been described in...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
This study evaluated the association between BRCA mutation status and serum anti-Müllerian hormone (AMH) level in young, reproductive-aged patients with breast cancer. Materials and Methods: Patients ≤ 40 years of age with breast cancer and who had known BRCA status and baseline serum AMH level at Samsung Medical Center, Seoul, Korea, were considered for inclusion. A total of 52 BRCA mutation carriers (27 BRCA1 and 25 BRCA2) and 264 non-carriers were selected for analyses. The serum level of AMH was compared according to presence of a BRCA mutation, and linear and logistic regression analyses were performed to eva...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Di Che1†, Yanfang Yang2†, Yufen Xu1†, Zhenzhen Fang3, Lei Pi1, LanYan Fu1, Huazhong Zhou1, Yaqian Tan1, Zhaoliang Lu1, Li Li4, Qihua Liang5, Qingshan Xuan4* and Xiaoqiong Gu1,5,6* 1Department of Clinical Biological Resource Bank, Guangzhou Institute of Pediatrics, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, China 2Department of Prenatal Diagnosis, Maoming People’s Hospital, Maoming, China 3Program of Molecular Medicine, Guangzhou Women and Children’s Hospital, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China 4...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
There is nothing more frustrating than when the cure is part of the problem. Because depression is prevalent in patients with physical disorders like cancer, stroke, and heart disease, medications often interact with each other, complicating treatment. To appropriately manage depression, you and your physician need to evaluate all medications involved and make sure they aren’t cancelling each other out. A review in the journal Dialogues in Clinical Neuroscience a while back highlighted certain medications that can cause depression. The following are medications to watch out for. Medications to Treat Seizures and Park...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Medications Drug Interactions Mood Disorder Source Type: blogs
Publication date: Available online 29 March 2019Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Yasmin Ali Abd El-Aal, Doaa Mohamed Abdel-Fattah, Khalifa El-Dawy AhmedAbstracttrans fatty acids (TFA's) are unsaturated fatty acid which have one or more double bond, they are present naturally and most of it is artificial, fried, baked food and margarine are major sources of TFA, there are several biological effects of TFAs on body health, various study showed that dietary TFA associated with various health disorders such as Diabetes, cardiovascular disease (CVD), Obesity, breast cancer, pros...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
The absolute of cancer remained very low at just 2%, and breast cancer was the most common type Related items fromOnMedica Only a third of women with regular bloating would see their GP Also in the press Fertility treatment does not appear to raise serious cancer risk Millennials top obesity chart before reaching middle age Reclassifying cancers 'will improve treatment'
Source: OnMedica Latest News - Category: UK Health Source Type: news
Every year, there are more adults who have been diagnosed with cancer at some point in their lives. All of them face the uncertainty and fear that follow cancer treatments. Research shows that fear of cancer recurrence interferes with emotional and physical well-being. And it also suggests that mind-body tools can help people who have been treated for cancer regain control. A growing number of cancer survivors Over the past 50 years, the number of adults who have completed primary treatment for cancer has grown steadily. By 2024, an estimated 19 million will be living in the United States, a tribute to rapidly evolving opt...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Breast Cancer Mental Health Mind body medicine Source Type: blogs
Abstract The combination of doxorubicin and cyclophosphamide commonly used to treat breast cancer can cause premature ovarian failure and infertility. α-Tocopherol is a potent antioxidant whereas γ-tocopherol causes apoptosis in a variety of cancer models in vitro including breast cancer. We hypothesised that the combination of doxorubicin (Dox) and 4-hydroperoxycyclophosphamide (4-Cyc) would be more cytotoxic in vitro than each agent alone, and that α-tocopherol would reduce and γ-tocopherol would augment the cytotoxicity of the combined chemotherapeutics. Human MCF-7 breast cancer and KGN...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
A study by the University of Aberdeen also found that the breast-cancer drug tamoxifen - which blocks oestrogen from fueling a tumour's growth - has a positive effect on a man's swimmers.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
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