Menactra (Polysaccharide Diphtheria Toxoid Conjugate Vaccine) - updated on RxList

Source: RxList - New and Updated Drug Monographs - Category: Drugs & Pharmacology Source Type: news

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Publication date: August 2018Source: The Lancet Global Health, Volume 6, Issue 8Author(s): Marilia Arndt Mesenburg, Maria Clara Restrepo-Mendez, Hugo Amigo, Alejandra D Balandrán, Maria Angelica Barbosa-Verdun, Beatriz Caicedo-Velásquez, Liliana Carvajal-Aguirre, Carlos E A Coimbra, Leonardo Z Ferreira, Maria del Pilar Flores-Quispe, Carlos Flores-Ramírez, Giovanna Gatica-Dominguez, Luis Huicho, Karla Jinesta-Campos, Ingrid S K Krishnadath, Fatima S Maia, Ivan A Marquez-Callisaya, Mercedes Marlene Martinez, Oscar J Mujica, Verónica PingraySummaryBackgroundLatin American and Caribbean populations...
Source: The Lancet Global Health - Category: International Medicine & Public Health Source Type: research
To support a fully liquid, diphtheria (D)-tetanus (T)-acellular pertussis (aP)-inactivated poliovirus (IPV)-hepatitis B (HB)-Haemophilus influenzae b (PRP-T) vaccine in Europe using a 2, 3, 4 month primary series and a booster at 11–15 months of age. Phase III, randomized, observer-blind studies in Germany and the Czech Republic. Participants who had not received HB vaccine were randomized to a 2, 3, 4 month primary series of DTaP-IPV-HB-PRP-T (group 1; N = 266) or a reconstituted DTaP-HB-IPV//PRP-T comparator (group 2; N = 263) and a booster of the same vaccine. Pneumococcal vaccine (PCV13) and rotavirus vaccine wer...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Vaccine Reports Source Type: research
Publication date: Available online 3 April 2018Source: Clinical Epidemiology and Global HealthAuthor(s): Harapan Harapan, Samsul Anwar, Herlina Dimiati, Zinatul Hayati, Mudatsir Mudatsir
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
ConclusionsCentralized reminder/recall was effective at increasing influenza vaccination rates in adults aged ≥65 years over a short time period, without burdening the practices, and at a reasonable cost.Trial RegistrationThis study is registered at www.clinicaltrials.gov NCT02133391.
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
This study’s objective was to examine the clinical effectiveness of prenatal Tdap, and whether effectiveness varies by gestational age at immunization.MethodsA nationwide cohort study of pregnant women with deliveries in 2010–2014 and their infants was performed. Commercial insurance claims data were analyzed in 2016–2017 to identify Tdap receipt by the pregnant women, and hospitalizations and outpatient visits for pertussis in their infants until the infants reached 18 months of age. Pertussis occurrence was compared between infants of mothers who received prenatal Tdap (overall and stratified by gestati...
Source: American Journal of Preventive Medicine - Category: International Medicine & Public Health Source Type: research
In this study, we aimed to investigate the immunogenicity of cationic liposomes loaded with diphtheria toxoid (DT) and poly(I:C) after hollow microneedle-mediated intradermal vaccination in mice. The following liposomal formulations were studied: DT loaded liposomes, a mixture of free DT and poly(I:C)-loaded liposomes, a mixture of DT-loaded liposomes and free poly(I:C), and liposomal formulations with DT and poly(I:C) either individually or co-encapsulated in the liposomes. Reference groups were DT solution adjuvanted with or without poly(I:C) (DT/poly(I:C)). The liposomal formulations were characterized in terms of parti...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
We present here a study of vaccine mixing and release following dissolution of filter-dried model protein and toxoid antigens within a single syringe, filter and needle unit. Release was better for filters made from glass than cellulose. Without additional mixing, uniformity was poor and only 41% of input protein was released from protein filter-dried onto glass fiber. In contrast, adding a simple glass bead and mixing by inversion, 100% release antigen solution was achieved, with uniform concentration at exit from the needle throughout a simulated injection. Adsorption onto alum adjuvant had no detectable effect on vaccin...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
Discussion Vaccines are a mainstay of infectious disease prevention and health promotion. Infants, children and adults benefit from vaccines the most when they are given on the recommended schedules. However there are times when this is not possible as children come to the physician a little early, or a little late, or had unavailable records and so received addition vaccine, etc. There are many questions that arise because of these timing issues such as the one above. Standard vaccine schedules can be reviewed here. Commonly administered vaccines includes: Live-attenuated vaccines Cholera Measles, mumps, rubella (MMR ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Combination vaccines represent a valuable technological innovation in the field of infectious disease prevention and public health, because of their great health and economic value from the individual, societal, and healthcare system perspectives.In order to increase parents ’ and healthcare professionals’ confidence in the vaccination programs and maintain their benefits to society, more information about the benefits of innovative vaccination tools such as combination vaccines is needed.Purpose of this work is an examination of available hexavalent vaccines, that protect against Diphtheria, Tetanus, Pertussis...
Source: Journal of Preventive Medicine and Hygiene - Category: International Medicine & Public Health Source Type: research
In this study, we aimed to investigate the immunogenicity of cationic liposomes loaded with diphtheria toxoid (DT) and poly(I:C) after hollow microneedle-mediated intradermal vaccination in mice. The following liposomal formulations were studied: DT loaded liposomes, a mixture of free DT and poly(I:C)-loaded liposomes, a mixture of DT-loaded liposomes and free poly(I:C), and liposomal formulations with DT and poly(I:C) either individually or co-encapsulated in the liposomes. Reference groups were DT solution adjuvanted with or without poly(I:C) (DT/poly(I:C)). The liposomal formulations were characterized in terms of parti...
Source: International Journal of Pharmaceutics - Category: Drugs & Pharmacology Source Type: research
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