Add-on Empagliflozin May Improve Glycemic Control and Weight Add-on Empagliflozin May Improve Glycemic Control and Weight
When type 2 diabetes is uncontrolled with linagliptin and metformin, adding empagliflozin helps improve glycemic control and weight, researchers say.Reuters Health Information
Publication date: Available online 21 January 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Inge B Halberg, Karsten Lyby, Karsten Wassermann, Tim Heise, Eric Zijlstra, Leona Plum-MörschelSummaryBackgroundOral insulin 338 (I338) is a long-acting, basal insulin analogue formulated in a tablet with the absorption-enhancer sodium caprate. We investigated the efficacy and safety of I338 versus subcutaneous insulin glargine (IGlar) in patients with type 2 diabetes.MethodsThis was a phase 2, 8-week, randomised, double-blind, double-dummy, active-controlled, parallel trial completed at two research institutes i...
ConclusionsIn this study, age was the strongest determinant of diabetes. And then type 2 diabetes is mainly attributable to WHR, significantly more so in women than men. Therefore, central obesity probably should be considered as a major strategy for reducing incidence of type 2 diabetes.
Authors: Ma R, Xu Y, Zhou H, Zhang D, Yao D, Song L, Liu Y Abstract The canonical transient receptor potential channel 6 ion channel is expressed in podocytes and is an important component of the glomerular slit diaphragm. Focal segmental glomerulosclerosis is closely associated with TRPC6 gene mutations, and TRPC6 mediates podocyte injury induced by high glucose. Angiotensin II (AngII) has been revealed to enhance TRPC6 currents in certain types of cells, including podocytes and ventricular myocytes. It has been reported that glucose regulated TRPC6 expression in an AngII‑dependent manner in podocytes and that t...
CONCLUSION: Dapagliflozin treatment was more cost-effective compared with metformin treatment for Chinese type 2 diabetes patients. However, the findings of favorable cost-effectiveness results for dapagliflozin are largely driven by the effects of favorable weight profile on clinical, utility and costs in the Cardiff model. PMID: 30663458 [PubMed - as supplied by publisher]
DIABETES type 2 symptoms can include unexplained weight loss, passing more urine than normal, and feeling very tired. But you could also be at risk of high blood sugar signs if you have any of these common symptoms that you could be ignoring.
TYPE 2 diabetes sufferers don ’t have to completely cut sweet treats out of their diets in order to lower blood sugar, but cutting down on sugar is advisable. If you have a sweet tooth and find it hard to cut down on certain foods, these five swaps can help you to lower your sugar and calorie intake without having to ditch you r favourite treats.
Background: Until date, the proportion of nonclassic monocytes in type 2 diabetic mellitus patientswith and without chronic periodontitis has not been evaluated based on glycemic control. Theobjective of this study was to compare the proportion of CD14+CD16++ monocytes in type 2diabetic patients with and without chronic periodontitis.Materials and Methods: In this cross sectional study A total of sixty individuals with type 2 diabetesmellitus (n = 15/group) were recruited. Individuals were grouped based on glycosylated hemoglobinA (HbA 1c) values and the presence of chronic periodontitis; Group 1 (diabetes mellitus with go...
Vagal nerve stimulation is gaining recognition as an important therapeutic approach especially for non-communicable diseases such as cardiovascular disease (CVD), Depression, Fibromyalgia, Arthritis, Type 2 Diabetes, Alzheimer, and certain types of cancer. In turn, decreased vagal tone its implicated in the prognosis of a wide range of diseases. Afferent vagal stimulation seems to have the key to reset certain pathophysiological states of the body leading to health improvement by reshaping neural networks.
Background: Type 2 Diabetes Mellitus (T2DM) accelerates cognitive aging and increases the risk for Alzheimer ’s disease (AD). Even non-demented older adults with T2DM show learning and memory impairments. Prior research has linked cortical hyperexcitability to memory dysfunction in AD. Our aim was to investigate if a similar association exists in T2DM.
Tarryn Willmer, Rabia Johnson, Johan Louw, Carmen Pheiffer